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33,508 results
  • Suspected eosinophilic pustular folliculitis presenting as rapidly evolving acneiform eruption. [Journal Article]
    J Eur Acad Dermatol Venereol 2019Damiani G, Pacifico A, … Morrone A
  • A 48-year-old African male presented to our Department of Dermatology, complaining of itchy papules and pustules rapidly spreading to cover the entire face (Fig. 1A -1B). Dermatological assessment revealed several sterile follicular itchy papulo-pustules arranged in annular clusters and superimposed in plaques, with a tendency for central clearing and peripheral expansion, on an erythematous lacq…
  • Extramedullary Hematopoiesis: An Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia. [Journal Article]
    Am J Dermatopathol 2019; 41(9):680-683Johnson NM, Thomas RJ, Grider DJ
  • Extramedullary hematopoiesis is the process of blood cell synthesis occurring outside the medulla of the bone marrow. During fetal development, extramedullary hematopoiesis is considered physiological; however, it is considered pathologic when occurring outside the neonatal period. Angiolymphoid hyperplasia with eosinophilia (ALHE) describes a lesion characterized histologically by plump endothel…
  • A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects. [Journal Article]
    J Clin Immunol 2019Cagdas D, Halaçlı SO, … Tezcan İ
  • CONCLUSIONS: Patients with LRBA deficiency may initially be diagnosed as CVID or ALPS in the clinical practice. Progressive decrease in B cells as well as IgG in ALPS-like patients and addition of IBD symptoms in the follow-up should raise the suspicion for LRBA deficiency. Decreased switched memory B cells, decreased naive and recent thymic emigrant (RTE) Th cells, and markedly increased effector memory/effector memory RA+ Th cells (TEMRA Th) cells are important for the diagnosis of the patients in addition to clinical features. Analysis of protein by either WB or flow cytometry is required when the clinicians come across especially with missense LRBA variants of uncertain significance. High rate of malignancy shows the regulatory T cell's important role of immune surveillance. HSCT is curative and succesful in patients with HLA-matched family donor.
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