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108,387 results
  • Flavivirus Infection- A Review of Immunopathogenesis, Immunological Response, and Immunodiagnosis. [Review]
    Virus Res 2019; :197770Chong HY, Leow CY, … Leow CH
  • Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection and epidemics on a global scale. It presents a significant health impact worldwide and the viruses have the potential to emerge and outbreak in a non-endemic geographical region. Effective vaccines for prophylaxis are only available for several flaviviruses such as Yellow Fever virus, Tick-borne Encephalitis…
  • Tuberculosis control in crisis-causes and solutions. [Review]
    Prog Biophys Mol Biol 2019Kaplan G
  • Tuberculosis incidence is projected to decline at too slow a rate to meet the targets set at the UN high level meeting on ending tuberculosis, convened in New York in 2018. To understand the causes of the slow progress in tuberculosis control, the Bill and Melinda Gates Foundation supported a patient-pathway analysis that identified significant gaps with patients being "lost" at all points along …
  • Association of Phlebotomus guggisbergi with L. major and L. tropica in a complex transmission setting for cutaneous leishmaniasis in Gilgil, Nakuru county, Kenya. [Journal Article]
    PLoS Negl Trop Dis 2019; 13(10):e0007712Owino BO, Matoke-Muhia D, … Masiga DK
  • CONCLUSIONS: The high infection rates of L. tropica and abundance of Ph. guggisbergi in this study confirms this sandfly as a vector of L. tropica in Kenya. Furthermore, isolation of live L. tropica parasites from Ph. saevus s.l. suggest that there are at least three potential vectors of this parasite species in Gilgil; Ph. guggisbergi, Ph. aculeatus and Ph. saevus s.l. Molecular identification of L. major infections in Ph. guggisbergi suggested this sandfly species as a potential permissive vector of L. major, which needs to be investigated further. Sandfly host preference analysis revealed the possibility of zoonotic transmissions of L. tropica in Gilgil since the main vector (Ph. guggisbergi) does not feed exclusively on humans but also other vertebrate species. Further investigations are needed to determine the potential role of these vertebrate species in L. tropica and L. major transmission in the area.
  • Dengue Fever in the Darfur Area, Western Sudan. [Journal Article]
    Emerg Infect Dis 2019; 25(11):2126Ahmed A, Ali Y, … Higazi T
  • We report an outbreak of dengue in Darfur, western Sudan, during September 2014-April 2015. Dengue virus-specific PCR testing of 50 samples from nonmalaria febrile illness case-patients confirmed 35 dengue cases. We detected 7 cases of dengue shock syndrome and 24 cases of dengue hemorrhagic fever.
  • Clinical REsearch During Outbreaks (CREDO) Training for Low- and Middle-Income Countries. [Journal Article]
    Emerg Infect Dis 2019; 25(11):2084-2087Kayem ND, Rojek A, … Horby P
  • We describe a pilot of the Clinical REsearch During Outbreaks (CREDO) initiative, a training curriculum for researchers in epidemic-prone low- and middle-income countries who may respond to disease outbreaks. Participants reported improved confidence in their ability to conduct such research and overall satisfaction with the course structure, content, and training.
  • The "Scourge of the Renaissance". A short review about Treponema pallidum infection. [Journal Article]
    Endocr Metab Immune Disord Drug Targets 2019Santacroce L, Bottalico L, … Charitos IA
  • CONCLUSIONS: The first of the three hypotheses about its origins is the Columbian hypothesis, which states that Columbus's crew acquired syphilis from Native Americans and carried it back to Europe in 1493 A. D. On the contrary, the second hypothesis (pre-Columbian) asserts that syphilis was present in Europe long before Columbus's voyage and was transferred to the New World by Columbus's men. The Unitarian theory argues that syphilis, bejel, yaws, and pinta are not separate diseases but they represent syndromes caused by slightly different strains of one organism. Nowadays, Syphilis' origin is still uncertain and remains controversial. However, the large impact on the social behavior and international public health is an important reason to investigate about its origins and how to prevent the transmission.
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