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Unbound Medicine.
(epigenesis)
35,138 results
  • Chicks from stressed females elicit overprotective behaviour in adoptive mother quail. [Journal Article]
    Behav Processes. 2020 Jul 06 [Online ahead of print]Aigueperse N, Houdelier C, … Lumineau S
  • Beyond the genetic links between mother and young, prenatal effects experienced by offspring can modulate their mother's behaviour and stress. Here we investigated the consequences of stress-induced prenatal maternal effects on quail chicks' behaviour and maternal behaviour. We evaluated how adoptive quail mothers (unstressed) raised chicks of females that had either been stressed (PS) or were no…
  • [Progress on epigenetic regulation of iron homeostasis]. [Review]
    Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25; 49(1):58-70.Duan L, Yin X, … Wang F
  • Iron homeostasis plays an important role for the maintenance of human health. It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and mi…
  • [Advances in research on the mechanism of DNA methylation in plants]. [Review]
    Sheng Wu Gong Cheng Xue Bao. 2020 May 25; 36(5):838-848.Yuan C, Zhang S, … Wang Z
  • DNA methylation is an epigenetic modification that forms an important regulation mechanism of gene expression in organisms across kingdoms. Aberrant patterns of DNA methylation can lead to plant developmental abnormalities. In this article, we briefly discuss DNA methylation in plants and summarize its functions and biological roles in regulating gene expression and maintaining genomic stability,…
  • Programming and reprogramming from conception till death [Journal Article]
    Orv Hetil. 2020 06; 161(25):1028-1034.Csaba G
  • During conception (fusion of maternal and paternal germ cells) a new entity is formed, which has individual structure and functions. From its gene-pool (genome) epigenetic regulation selects those genes which are durably or acutely working, supplying a theoretically lifelong program. However, this program could be changed spontaneously or artificially, and there are life periods when the spontane…
  • Epigenetic Molecular Mechanisms in Insects. [Review]
    Neotrop Entomol. 2020 Jun 08 [Online ahead of print]Villagra C, Frías-Lasserre D
  • Insects are the largest animal group on Earth both in biomass and diversity. Their outstanding success has inspired genetics and developmental research, allowing the discovery of dynamic process explaining extreme phenotypic plasticity and canalization. Epigenetic molecular mechanisms (EMMs) are vital for several housekeeping functions in multicellular organisms, regulating developmental, ontogen…
  • Blood DNA methylation and type 2 diabetes mellitus: A protocol for systematic review and meta-analysis. [Journal Article]
    Medicine (Baltimore). 2020 Jun 05; 99(23):e20530.Wang X, Yang J, … Chen Q
  • Epidemiology of type 2 diabetes (T2D) is affected by genetic and environmental factors. Deoxyribonucleic acid (DNA) methylation as a kind of epigenetic mechanism has been reported to affect the pathogenesis of T2D. Both global DNA methylation and candidate genes were observed differentially methylated and identified changes. Peripheral blood biomarkers could have significant clinical utility due …
  • poly(UG)-tailed RNAs in genome protection and epigenetic inheritance. [Journal Article]
    Nature. 2020 06; 582(7811):283-288.Shukla A, Yan J, … Kennedy S
  • Mobile genetic elements threaten genome integrity in all organisms. RDE-3 (also known as MUT-2) is a ribonucleotidyltransferase that is required for transposon silencing and RNA interference in Caenorhabditis elegans1-4. When tethered to RNAs in heterologous expression systems, RDE-3 can add long stretches of alternating non-templated uridine (U) and guanosine (G) ribonucleotides to the 3' termin…
  • Why does COVID-19 disproportionately affect older people? [Journal Article]
    Aging (Albany NY). 2020 05 29; 12(10):9959-9981.Mueller AL, McNamara MS, Sinclair DA
  • The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23-fold greater risk of death than those under 65. In the clinic, COVID-19 patients most commonly present with fever, cough and dyspnea, and from there the disease can progress to acute respiratory distress syndrome, lung cons…
  • Nonequilibrium Strategy for Fast Target Search on the Genome. [Journal Article]
    Phys Rev Lett. 2020 May 15; 124(19):198101.Cagnetta F, Michieletto D, Marenduzzo D
  • Vital biological processes such as genome repair require fast and efficient binding of selected proteins to specific target sites on DNA. Here we propose an active target search mechanism based on "chromophoresis," the dynamics of DNA-binding proteins up or down gradients in the density of epigenetic marks, or colors (biochemical tags on the genome). We focus on a set of proteins that deposit mar…
  • The Epigenetic Regulation of Scleroderma and Its Clinical Application. [Journal Article]
    Adv Exp Med Biol. 2020; 1253:375-403.Luo Y, Xiao R
  • Scleroderma (systemic sclerosis; SSc) is a complex and highly heterogeneous multisystem rheumatic disease characterized by vascular abnormality, immunologic derangement, and excessive deposition of extracellular matrix (ECM) proteins. To date, the etiology of this life-threatening disorder remains not fully clear. More and more studies show epigenetic modifications play a vital role. The aberrant…
  • Epigenetics in Multiple Sclerosis. [Journal Article]
    Adv Exp Med Biol. 2020; 1253:309-374.Chan VS
  • Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal antigens is the key to the pathogenesis of MS, with autoreactive T cells causing demyelination that subsequently leads to inflammation-mediated neurodegenerative events in the central nervous system. The exact etiol…
  • Epigenetics in Primary Sjögren's Syndrome. [Review]
    Adv Exp Med Biol. 2020; 1253:285-308.Bordron A, Devauchelle-Pensec V, … Renaudineau Y
  • Primary Sjögren's syndrome (SjS) is a chronic and systemic autoimmune epithelitis with predominant female incidence, which is characterized by exocrine gland dysfunction. Incompletely understood, the etiology of SjS is multi-factorial and evidence is growing to consider that epigenetic factors are playing a crucial role in its development. Independent from DNA sequence mutations, epigenetics is d…
  • Epigenetics of Primary Biliary Cholangitis. [Review]
    Adv Exp Med Biol. 2020; 1253:259-283.Li Y, Tang R, Ma X
  • Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with non-suppurative destruction of the intrahepatic bile ducts. The interplay of genetics and environmental triggers contributes to the onset of the disease and subsequently results in cholestasis and progressive fibrosis. Recently, genome-wide association studies (GWAS) have identified multiple genes influencing the suscep…
  • The Role of Epigenetics in Type 1 Diabetes. [Review]
    Adv Exp Med Biol. 2020; 1253:223-257.Xie Z, Chang C, … Zhou Z
  • Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction between genetic alterations and environmental factors. More than 60 susceptible genes or loci of T1D have been identified. Among them, HLA regions are reported to contribute about 50% of genetic susceptibility in Caucasians. There are many environmental factors involved in the pathogenesis of T1D. Environmental factors may c…
  • Epigenetics of Psoriasis. [Review]
    Adv Exp Med Biol. 2020; 1253:209-221.Shao S, Gudjonsson JE
  • Psoriasis is a chronic and recurrent inflammatory skin disease, involving the rapid proliferation and abnormal differentiation of keratinocytes and activation of T cells. It is generally accepted that the central pathogenesis of psoriasis is a T cell-dominant immune disorder affected by multiple factors including genetic susceptibility, environmental factors, innate and adaptive immune responses,…
  • The Epigenetics of Lupus Erythematosus. [Review]
    Adv Exp Med Biol. 2020; 1253:185-207.Wu H, Chang C, Lu Q
  • Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease that is characterized by dysregulated dendritic cells, T and B cells, and abundant autoantibodies. The pathogenesis of lupus remains unclear. However, increasing evidence has shown that environment factors, genetic susceptibilities, and epigenetic regulation contribute to abnormalities in the immune system. In the past de…
  • Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis. [Review]
    Adv Exp Med Biol. 2020; 1253:153-181.Long A, Bunning B, … Nadeau KC
  • Asthma and rhinitis are complex, heterogeneous diseases characterized by chronic inflammation of the upper and lower airways. While genome-wide association studies (GWAS) have identified a number of susceptible loci and candidate genes associated with the pathogenesis of asthma and allergic rhinitis (AR), the risk-associated alleles account for only a very small percent of the genetic risk. In al…
  • The Epigenetics of Food Allergy. [Review]
    Adv Exp Med Biol. 2020; 1253:141-152.Chang C, Wu H, Lu Q
  • Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental…
  • The Role of Genetics, the Environment, and Epigenetics in Atopic Dermatitis. [Review]
    Adv Exp Med Biol. 2020; 1253:107-140.Mu Z, Zhang J
  • Atopic Dermatitis (AD) is a common inflammatory disease with a genetic background. The prevalence of AD has been increasing in many countries. AD patients often have manifestations of pruritus, generalized skin dryness, and eczematous lesions. The pathogenesis of AD is complicated. The impaired skin barrier and immune imbalance play significant roles in the development of AD. Environmental factor…
  • Epigenetic Methods and Twin Studies. [Review]
    Adv Exp Med Biol. 2020; 1253:95-104.Ceribelli A, Selmi C
  • Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseas…
  • The Development of Epigenetics in the Study of Disease Pathogenesis. [Review]
    Adv Exp Med Biol. 2020; 1253:57-94.Jeffries MA
  • The study of epigenetics has its roots in the study of organism change over time and response to environmental change, although over the past several decades the definition has been formalized to include heritable alterations in gene expression that are not a result of alterations in underlying DNA sequence. In this chapter, we discuss first the history and milestones in the 100+ years of epigene…
  • Epigenetics in Health and Disease. [Review]
    Adv Exp Med Biol. 2020; 1253:3-55.Zhang L, Lu Q, Chang C
  • Epigenetic mechanisms, which include DNA methylation, histone modification, and microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA sequence. Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. Mechanisms of epigenetics include DNA methylation (and demethylation), histone mo…
  • On the problem of biological form. [Journal Article]
    Theory Biosci. 2020 May 16 [Online ahead of print]Linde-Medina M
  • Embryonic development, which inspired the first theories of biological form, was eventually excluded from the conceptual framework of the Modern Synthesis as irrelevant. A major question during the last decades has centred on understanding whether new advances in developmental biology are compatible with the standard view or whether they compel a new theory. Here, I argue that the answer to this …
  • Transgenerational transmission of neurodevelopmental disorders induced by maternal exposure to PM2.5. [Journal Article]
    Chemosphere. 2020 Sep; 255:126920.Zhou Y, Zhang M, … Xu Y
  • The pathological traits or diseases susceptibility caused by maternal exposure to environmental adverse insults (infection, malnutrition, environmental toxicants) could be transmitted across generations. It remains uncertain, however, whether the neurodevelopmental disturbances of offspring induced by maternal exposure to PM2.5 during early life can be inherited by subsequent generations without …
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