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31,648 results
  • [Most recent findings on microRNA-dependent regulation of drug metabolism]. [Review]
    Nihon Yakurigaku Zasshi 2019; 154(1):28-34Nakano M, Nakajima M
  • Drug metabolism is an important determinant to control pharmacokinetics, drug response and drug toxicity. Large variabilities are observed in expression or activity of drug-metabolizing enzymes such as cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT). Therefore, understanding of the causes for the variation of drug metabolism potencies is essential for efficient drug development and pr…
  • [Gene editing technology and its recent progress in disease therapy]. [Review]
    Yi Chuan 2019; 41(7):582-598Niu XR, Yin SM, … Li DL
  • Gene editing is a genetic manipulation technology which utilizes bacterial nucleases to accurately and efficiently modify DNA or RNA. Gene editing has broad applications in basic research, breeding, and drug screening, and it is gaining validity and applicability to the therapy of many diseases especially genetic-based disease. In this review, we summarize the development of gene editing technolo…
  • [Epigenetics in the genesis and development of cancers]. [Review]
    Yi Chuan 2019; 41(7):567-581Zhang JW, Xu Q, Li GL
  • Cancer is a complex disease caused by the malignant cellular proliferation and metastasis. Elucidating its pathogenic mechanism is one of the major challenges that we face currently. Epigenetic mechanisms are essential for maintaining specific patterns of gene expression and normal development and growth of living individuals. Disorders of epigenetic markers, such as histone modification, DNA/RNA…
  • Tracing the origin and evolution history of methylation-related genes in plants. [Journal Article]
    BMC Plant Biol 2019; 19(1):307Pei L, Zhang L, … Wang M
  • CONCLUSIONS: The study describes a global characterization of DNA methylation-related genes in the plant kingdom. The similarities and differences in origin time, gene structure and phylogenetic relationship of these genes lead us to understand the evolutionary conservation and dynamics of DNA methylation in plants.
  • Cell type-specific epigenetic links to schizophrenia risk in the brain. [Journal Article]
    Genome Biol 2019; 20(1):135Mendizabal I, Berto S, … Yi SV
  • CONCLUSIONS: Our results provide novel and comprehensive methylome and transcriptome data from distinct cell populations within patient-derived brain tissues. This data clearly demonstrate that cell type epigenetic-differentiated sites are preferentially targeted by disease-associated epigenetic dysregulation. We further show reduced cell type epigenetic distinction in schizophrenia.
  • Histone deacetylases in stroke. [Review]
    Chin J Physiol 2019 May-Jun; 62(3):95-107Kao MH, Lin TN
  • Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability to interact with not one, but multiple pathophysiological cascades at …
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