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73,485 results
  • Mutational profiling in myelofibrosis: implications for management. [Review]
    Int J Hematol 2019Bose P, Verstovsek S
  • Mutational profiling, usually by targeted next-generation sequencing, is increasingly performed on patients with myeloproliferative neoplasm-associated myelofibrosis (MF), whether primary (PMF) or post-polycythemia vera/essential thrombocythemia (post-PV/ET MF). "Driver" mutations in JAK2, MPL and indels in CALR underlie the vast majority of cases of PMF and post-ET MF; the remainder (≈ 10%) lack…
  • The dynamic chromatin architecture of the regenerating liver. [Journal Article]
    Cell Mol Gastroenterol Hepatol 2019Wang AW, Wang YJ, … Kaestner KH
  • CONCLUSIONS: Our analysis of hepatocyte-specific epigenomic changes during liver repopulation identified CTCF and HNF4α as key regulators of hepatocyte proliferation and regulation of metabolic programs. Thus, liver repopulation in the setting of toxic injury makes use of both general transcription factors (CTCF) for promoter activation, and reduced binding by a hepatocyte-enriched factor (HNF4α) to temporarily limit enhancer activity.
  • Cys2His2 zinc finger methyl-CpG binding proteins: Getting a handle on methylated DNA. [Review]
    J Mol Biol 2019Hodges AJ, Hudson NO, Buck-Koehntop BA
  • DNA methylation is an essential epigenetic modification involved in the maintenance of genomic stability, preservation of cellular identity, and regulation of the transcriptional landscape needed to maintain cellular function. In an increasing number of disease conditions, DNA methylation patterns are inappropriately distributed in a manner that supports the disease phenotype. Methyl-CpG binding …
  • Micro(RNA) management and mismanagement of the islet. [Review]
    J Mol Biol 2019Eliasson L, Regazzi R
  • Pancreatic β-cells located within the islets of Langerhans play a central role in metabolic control. The main function of these cells is to produce and secrete insulin in response to a rise in circulating levels of glucose and other nutrients. The release of insufficient insulin to cover the organism needs results in chronic hyperglycemia and diabetes development. β-cells insure a highly speciali…
  • Artificial intelligence and the detection of pediatric concussion using epigenomic analysis. [Journal Article]
    Brain Res 2019; :146510Bahado-Singh RO, Vishweswaraiah S, … Radhakrishna U
  • Concussion, also referred to as mild traumatic brain injury (mTBI) is the most common type of traumatic brain injury. Currently concussion is an area ofintensescientific interest to better understand the biological mechanisms and for biomarker development. We evaluated whole genome-wide blood DNA cytosine ('CpG') methylation in 17 pediatric concussion isolated cases and 18 unaffected controls usi…
  • The mechanism and function of active DNA demethylation in plants. [Review]
    J Integr Plant Biol 2019Liu R, Lang Z
  • DNA methylation is a conserved and important epigenetic mark in both mammals and plants. DNA methylation can be dynamically established, maintained and removed through different pathways. In plants, active DNA demethylation is initiated by the ROS1 family of bifunctional DNA glycosylases/lyases. Accumulating evidence suggests that DNA demethylation is important in many processes in plants. In thi…
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