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257,503 results
  • Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates. [Journal Article]
    Front Neurosci 2019; 13:759Williams JJ, Watson AM, … Schwartz AB
  • Objective: Reanimation of muscles paralyzed by disease states such as spinal cord injury remains a highly sought therapeutic goal of neuroprosthetic research. Optogenetic stimulation of peripheral motor nerves expressing light-sensitive opsins is a promising approach to muscle reanimation that may overcome several drawbacks of traditional methods such as functional electrical stimulation (FES). …
  • Functional anatomy of the nerve and optimal placement of the needle for successful (and) safe nerve blocks. [Journal Article]
    Curr Opin Anaesthesiol 2019Franco CD, Sala-Blanch X
  • CONCLUSIONS: It is necessary to have a better understanding of what intraneural injection is when dealing with any type of nerve blocks, be that single nerve, plexuses, or the sciatic nerve. Perineural injections provide successful anesthesia without putting the nerve integrity at risk. That practice is supported by years of experience and common sense. Currently, there is no evidence to support any kind of intraneural injections, intrafascicular or extrafascicular.
  • MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis. [Journal Article]
    Brain 2019Morquette B, Juźwik CA, … Fournier AE
  • Multiple sclerosis is a chronic inflammatory, demyelinating, and neurodegenerative disease affecting the brain, spinal cord and optic nerves. Neuronal damage is triggered by various harmful factors that engage diverse signalling cascades in neurons; thus, therapeutic approaches to protect neurons will need to focus on agents that can target multiple biological processes. We have therefore focused…
  • Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X. [Journal Article]
    Hum Mol Genet 2019Kagiava A, Richter J, … Kleopa KA
  • X-linked Charcot-Marie-Tooth disease (CMT1X), one of the commonest forms of inherited demyelinating neuropathy, results from GJB1 gene mutations causing loss of function of the gap junction protein connexin32 (Cx32). The aim of this study was to examine whether delayed gene replacement therapy after the onset of peripheral neuropathy can provide a therapeutic benefit in the Gjb1-null/Cx32 knockou…
  • Pathophysiology and management of monoclonal gammopathy of renal significance. [Review]
    Blood Adv 2019; 3(15):2409-2423Jain A, Haynes R, … Ramasamy K
  • Recent years have witnessed a rapid growth in our understanding of the pathogenic property of monoclonal proteins. It is evident that some of these small monoclonal proteins are capable of inducing end-organ damage as a result of their intrinsic physicochemical properties. Hence, an umbrella term, monoclonal gammopathy of clinical significance (MGCS), has been coined to include myriad conditions …
  • [Advance of vascularization of tissue engineered peripheral nerve]. [Journal Article]
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019; 33(8):1029-1032Zhao B, Ma J, Ma X
  • CONCLUSIONS: Promoting early vascularization of tissue engineered peripheral nerves can provide timely nutritional support for seed cells on the scaffold, promote axon growth and nerve regeneration, and facilitate the repair of large peripheral nerve defects in clinical practice.
  • Clinical and research applications of neuromuscular ultrasound in amyotrophic lateral sclerosis. [Journal Article]
    Degener Neurol Neuromuscul Dis 2019; 9:89-102Barnes SL, Simon NG
  • Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by dysfunction at multiple levels of the neuraxis. It remains a clinical diagnosis without a definitive diagnostic investigation. Electrodiagnostic testing provides supportive information and, along with imaging and biochemical markers, can help exclude mimicking conditions. Neuromuscular ultrasound has …
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