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366,726 results
  • Similarity and difference in the characteristics of eosinophilic esophagitis between Western countries and Japan. [Review]
    Dig Endosc. 2020 Jul 05 [Online ahead of print]Ishimura N, Okimoto E, … Ishihara S
  • Over the past two decades, the incidence and prevalence of eosinophilic esophagitis (EoE) has risen rapidly, especially in Western countries, with cases in Japan also showing a gradual increase in recent years. However, similarities and differences regarding the characteristics of EoE between Western countries and Japan remain to be clearly elucidated. The current clinical guidelines for diagnosi…
  • Zika virus infection causes widespread damage to the inner ear. [Journal Article]
    Hear Res. 2020 Jun 29; 395:108000.Yee KT, Neupane B, … Vetter DE
  • Zika virus (ZIKV) has been recently recognized as a causative agent of newborn microcephaly, as well as other neurological consequences. A less well recognized comorbidity of prenatal ZIKV infection is hearing loss, but cases of hearing impairment following adult ZIKV infection have also been recognized. Diminished hearing following prenatal ZIKV infection in a mouse model has been reported, but …
  • Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs. [Journal Article]
    Toxicol In Vitro. 2020 Jul 02 [Online ahead of print]Belair DG, Visconti RJ, … Kolaja KL
  • Drug-induced gastrointestinal toxicity (GIT) is a common treatment-emergent adverse event that can negatively impact dosing, thereby limiting efficacy and treatment options for patients. An in vitro assay of GIT is needed to address patient variability, mimic the microphysiology of the gut, and accurately predict drug-induced GIT. Primary human ileal organoids (termed 'enteroids') have proven use…
  • Effects of short-term exposure to high-fat diet on histology of male and female gonads in rats. [Journal Article]
    Acta Histochem. 2020 Jul; 122(5):151558.Matuszewska J, Ziarniak K, … Śliwowska JH
  • Obesity, which reaches an epidemic, is characterized by alterations in metabolic and hormonal profiles. Moreover, uncontrolled obesity may lead to development of diabetes type 2, which accounts for about 90% of all diabetic cases. In obesity, besides changes in metabolism, numerous co-morbidities are reported, e.g. disruptions of reproductive functions. Additionally, sex differences in developmen…
  • A novel mechanism in wound healing: Laminin 332 drives MMP9/14 activity by recruiting syndecan-1 and CD44. [Journal Article]
    Matrix Biol. 2020 Jul 01 [Online ahead of print]Michopoulou A, Montmasson M, … Rousselle P
  • Re-epithelialization describes the resurfacing of a skin wound with new epithelium. In response to various stimuli including that of growth factors, cytokines and extracellular matrix (ECM), wound edge epidermal keratinocytes undergo cytoskeleton rearrangements compatible with their motile behaviour and develop protrusive adhesion contacts. Matrix metalloproteinases (MMP) expression is crucial fo…
  • Submucosal gland neoplasms of the esophagus: an update and review. [Review]
    Esophagus. 2020 Jul 03 [Online ahead of print]Nie L, Li W, … Fan X
  • Submucosal glands (SMGs) present throughout human esophagus with clusters at either the upper third or lower third of the organ. SMGs tend to atrophy with age, and neoplasms arising in these glands are rare. In order to bring convenience to diagnosis, we summarize the histopathologic characteristics of all esophageal submucosal gland tumors (SGTs). Due to the morphological similarity, the nomencl…
  • Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice. [Journal Article]
    Nat Commun. 2020 Jul 03; 11(1):3350.Zak JD, Reddy G, … Murthy VN
  • Odor landscapes contain complex blends of molecules that each activate unique, overlapping populations of olfactory sensory neurons (OSNs). Despite the presence of hundreds of OSN subtypes in many animals, the overlapping nature of odor inputs may lead to saturation of neural responses at the early stages of stimulus encoding. Information loss due to saturation could be mitigated by normalizing m…
  • Modeling the cornea in 3-dimensions: Current and future perspectives. [Review]
    Exp Eye Res. 2020 Jun 30 [Online ahead of print]McKay TB, Hutcheon AEK, … Karamichos D
  • The cornea is an avascular, transparent ocular tissue that serves as a refractive and protective structure for the eye. Over 90% of the cornea is composed of a collagenous-rich extracellular matrix within the stroma with the other 10% composed by the corneal epithelium and endothelium layers and their corresponding supporting collagen layers (e.g., Bowman's and Descemet's membranes) at the anteri…
  • Folliculocystic and Collagen Hamartoma: A Distinct Hamartoma Associated With Tuberous Sclerosis Complex. [Journal Article]
    Am J Dermatopathol. 2020 Jun 30 [Online ahead of print]Cardona R, Cancel-Artau KJ, … Martin-Garcia RF
  • Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by cutaneous and extracutaneous hamartomas. Dermatologic evaluation is critical for early diagnosis because mucocutaneous manifestations account for 4 of 11 major and 3 of 6 minor diagnostic criteria. Folliculocystic and collagen hamartoma (FCCH) is a recently described entity associated with TSC. We herein describe the ca…
  • Generation of Pecam1 endothelial specific dual reporter mouse model. [Journal Article]
    Genesis. 2020 Jul 03 [Online ahead of print]Hu D, Zhang L, … Cai CL
  • Endothelial cells are specialized epithelium lining the interior surface of vessels and play fundamental roles in angiogenesis, vascular permeability, and immune response. To identify endothelial cells in vivo, we constructed a Pecam1nlacZ-H2B-GFP/+ knock-in mouse model in which the endothelial cells are labeled by nuclear LacZ (nlacZ) expression. When Pecam1nlacZ-H2B-GFP/+ mice are bred with ger…
  • Proper E-cadherin membrane location in colon requires Dab2 and it modifies by inflammation and cancer. [Journal Article]
    J Cell Physiol. 2020 Jul 02 [Online ahead of print]Vazquez-Carretero MD, García-Miranda P, … Peral MJ
  • We reported that Disabled-2 (Dab2) is located at the apical membrane in suckling rat intestine. Here, we discovered that, in colon of suckling and adult mouse and of adult human, Dab2 is only at lateral crypt cell membrane and colocalized with E-cadherin. Dab2 depletion in Caco-2 cells led to E-cadherin internalization indicating that its membrane location requires Dab2. In mice, we found that 3 …
  • Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10949.Jespersen K, Liu Z, … Xiong W
  • Marfan syndrome (MFS) is a heritable disorder of connective tissue, caused by mutations in the fibrillin-1 gene. Pulmonary functional abnormalities, such as emphysema and restrictive lung diseases, are frequently observed in patients with MFS. However, the pathogenesis and molecular mechanism of pulmonary involvement in MFS patients are underexplored. Notch signaling is essential for lung develop…
  • Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. [Journal Article]
    Biol Open. 2020 Jul 02; 9(6)Fabik J, Kovacova K, … Machon O
  • Cranial neural crest cells (cNCCs) originate in the anterior neural tube and populate pharyngeal arches in which they contribute to formation of bone and cartilage. This cell population also provides molecular signals for the development of tissues of non-neural crest origin, such as the tongue muscles, teeth enamel or gland epithelium. Here we show that the transcription factor Meis2 is expresse…
  • The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii. [Journal Article]
    Korean J Parasitol. 2020 Jun; 58(3):237-247.Choi HG, Gao FF, … Cha GH
  • Dendritic cell is one of the first innate immune cell to encounter T. gondii after the parasite crosses the host intestinal epithelium. T. gondii requires intact DC as a carrier to infiltrate into host central nervous system (CNS) without being detected or eliminated by host defense system. The mechanism by which T. gondii avoids innate immune defense of host cell, especially in the dendritic cel…
  • Neurosurgical Pathology and Management of Limited Dorsal Myeloschisis Associated with Congenital Dermal Sinus in Infancy. [Case Reports]
    Pediatr Neurosurg. 2020 Jul 02 [Online ahead of print]Morioka T, Murakami N, … Iihara K
  • CONCLUSIONS: Surgeons should be aware of the approximately 10% possibility of the coexistence of CDS when managing infant LDM. However, the recommendation for excision of the entire length of the LDM stalk in all patients should be more carefully made because such a strategy may result in an unnecessary extent of laminotomy/laminectomy for most patients with pure LDM. However, once the postoperative histological examination reveals coexistence of CDS in the resected proximal part of the stalk, the entire length of the remnant stalk should be excised as soon as possible.
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