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1,202 results
  • Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection. [Journal Article]
    Antiviral Res. 2020 Jul; 179:104808.Fatma B, Kumar R, … Tomar S
  • Chikungunya virus (CHIKV) is an arthritogenic alphavirus and currently, no antiviral drug is available to combat it. Capsid protein (CP) of alphaviruses present at the N-terminus of the structural polyprotein possesses auto-proteolytic activity which is essential for initiating the structural polyprotein processing. We are reporting for the first time antiviral molecules targeting capsid proteoly…
  • StatPearls: Glycoprotein IIb/IIIa Inhibitors [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Tummala Ramyashree R Mount Sinai Beth Israel Rai Manoj P. MP Asante Rogue Regional Medical Center BOOK
  • Platelets are responsible for the formation of thrombus after endothelial injury, which is vital in maintaining normal hemostasis. Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors prevent platelet aggregation by blocking glycoprotein IIb/IIIa receptors; thus they found application in the management of coronary artery disease (CAD). The available GP IIb/IIIa inhibitors include abciximab, tirofiban, …
  • Management of a decompensated acute-on-chronic intracranial venous sinus thrombosis. [Case Reports]
    Ther Adv Neurol Disord. 2019; 12:1756286419895157.Serna Candel C, Hellstern V, … Henkes H
  • A 34-year-old female patient presented during the 10th week of her second gravidity with headache, nausea and vomiting 2 weeks before admission. Her medical history was remarkable for a heterozygous factor V Leiden mutation, elevated lipoprotein A, and a cerebral venous thrombosis (CVT) after oral contraceptive intake 15 years before. Magnetic resonance imaging (MRI) suggested acute and massive i…
  • A Novel αIIbβ3 Antagonist from Snake Venom Prevents Thrombosis without Causing Bleeding. [Journal Article]
    Toxins (Basel). 2019 12 21; 12(1)Kuo YJ, Chung CH, … Huang TF
  • Life-threatening thrombocytopenia and bleeding, common side effects of clinically available αIIbβ3 antagonists, are associated with the induction of ligand-induced integrin conformational changes and exposure of ligand-induced binding sites (LIBSs). To address this issue, we examined intrinsic mechanisms and structure-activity relationships of purified disintegrins, from Protobothrops flavoviridi…
  • Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving. [Review]
    Toxins (Basel). 2019 09 25; 11(10)Mohamed Abd El-Aziz T, Garcia Soares A, Stockand JD
  • Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact, venoms are complex mixtures of enzymatic and non-enzymatic components with specific pathophysiological functions. Peptide toxins isolated from animal venoms target mainly ion channels, membrane receptors and components of the hemostatic system with high selectivity and affinity. The present review shows an up-…
  • Drugs and Lactation Database (LactMed): Eptifibatide [BOOK]
    . National Library of Medicine (US): Bethesda (MD)BOOK
  • No published information is available on the use of eptifibatide during breastfeeding. Because eptifibatide is a peptide, absorption by the infant is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, eptifibatide should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. If it is used by…
  • From Snake Venom's Disintegrins and C-Type Lectins to Anti-Platelet Drugs. [Review]
    Toxins (Basel). 2019 05 27; 11(5)Lazarovici P, Marcinkiewicz C, Lelkes PI
  • Snake venoms are attractive natural sources for drug discovery and development, with a number of substances either in clinical use or in research and development. These drugs were developed based on RGD-containing snake venom disintegrins, which efficiently antagonize fibrinogen activation of αIIbβ3 integrin (glycoprotein GP IIb/IIIa). Typical examples of anti-platelet drugs found in clinics are …
  • Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: A narrative review. [Review]
    Rev Port Cardiol. 2019 04; 38(4):289-297.Caldeira D, Pereira H
  • This article reviews the major pharmacologic features of, and clinical evidence on, adjuvant medical therapy in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. These drugs include oral antiplatelets (aspirin and P2Y12 inhibitors such as clopidogrel, prasugrel and ticagrelor), intravenous antiplatelet agents (the P2Y12 inhibitor can…
  • StatPearls: Eptifibatide [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Bansal Agam B. AB Cleveland Clinic, Ohio Sattar Yasar Y Icahn School of Medicine at Mount Sinai Jamil Radia T. RT Allama Iqbal Medical College BOOK
  • Eptifibatide is an antiplatelet drug that reversibly binds and inhibits glycoprotein IIb/IIIa receptor of platelets. A protein found in the venom of a southeastern pygmy rattlesnake is used to make eptifibatide. The PURSUIT and IMPACT-II account for the indications of eptifibatide by Food and Drug Administration(FDA)as mentioned below:
  • Validated High Performance Liquid Chromatographic Method for Stability Study of Eptifibatide. [Journal Article]
    J Chromatogr Sci. 2019 Jul 01; 57(6):541-551.Elzanfaly ES, Amer EAE, … Zaazaa HE
  • Eptifibatide (EPT) is a cyclic heptapeptide derived from a protein found in the venom of the south-eastern pygmy rattle snake used as an antiplatelet drug. In this study, a newly developed HPLC method demonstrating no interference from the different degradation products of EPT has been optimized and validated. The method was based on HPLC separation of eptifibatide from its degradation products u…
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