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30,189 results
  • Metabolic study of vardenafil analogues: Pseudovardenafil and hydroxyvardenafil. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci 2019; 1139:121940Heo D, Kang JS, … Pyo J
  • Vardenafil, a remedy for erectile dysfunction, is easily modified, facilitating the creation of analogues that have been illegally added to functional foods and counterfeit medications. However, the medical profile of these analogues, including their safety, efficacy, safe drug combinations, metabolism and excretion, has not been completely evaluated, which could cause serious health problems. In…
  • Development of novel phosphodiesterase 5 inhibitors for the therapy of alzheimer's disease. [Review]
    Biochem Pharmacol 2020; :113818Zuccarello E, Acquarone E, … Fiorito J
  • Nitric oxide (NO) is a gaseous molecule that plays a multifactorial role in several cellular processes. In the central nervous system, the NO dual nature in neuroprotection and neurotoxicity has been explored to unveil its involvement in Alzheimer's disease (AD). A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription fa…
  • Recurrent chordee in 59 adolescents and young adults following childhood hypospadias repair. [Journal Article]
    J Pediatr Urol 2019Abosena W, Talab SS, Hanna MK
  • CONCLUSIONS: Recurrent curvature in adolescents following hypospadias repair, may be caused by peri-urethral and skin fibrosis and/or disproportionate growth of the relatively hypoplastic ventral corporal wall or the reconstructed urethra. Surgical correction of symptomatic patients by dorsal shortening or ventral lengthening procedures depends on the degree of curvature following skin degloving of the penis. We have been recommending to parents of children born with proximal hypospadias who had what appeared to be a good surgical result to follow up after puberty.
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