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20,701 results
  • Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia. [Journal Article]
    G3 (Bethesda) 2019Chen C, Huang H, … Qin W
  • Ribosome is a vital molecular machine for protein translation in the cell. Defects in several ribosomal proteins including PRS19, RPL11 and RPS14 have been observed in two types of anemia: Diamond Blackfan Anemia and 5q- syndrome. In zebrafish, deficiency of these ribosomal proteins shows similar anemia phenotype. It remains to be determined if any other ribosome proteins are similarly involved i…
  • Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways. [Review]
    Antioxidants (Basel) 2019; 8(10)Duvigneau JC, Esterbauer H, Kozlov AV
  • The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron. Although mostly beneficial, the HO reaction can also produce deleterious effects, predominantly attributed to excessive product formation. Underrated so far is, however, that HO may exert effects addition…
  • Anemia of Inflammation with An Emphasis on Chronic Kidney Disease. [Review]
    Nutrients 2019; 11(10)Begum S, Latunde-Dada GO
  • Iron is vital for a vast variety of cellular processes and its homeostasis is strictly controlled and regulated. Nevertheless, disorders of iron metabolism are diverse and can be caused by insufficiency, overload or iron mal-distribution in tissues. Iron deficiency (ID) progresses to iron-deficiency anemia (IDA) after iron stores are depleted. Inflammation is of diverse etiology in anemia of chro…
  • Heat shock protein 60 regulates yolk sac erythropoiesis in mice. [Journal Article]
    Cell Death Dis 2019; 10(10):766Duan Y, Wang H, … Ouyang K
  • The yolk sac is the first site of blood-cell production during embryonic development in both murine and human. Heat shock proteins (HSPs), including HSP70 and HSP27, have been shown to play regulatory roles during erythropoiesis. However, it remains unknown whether HSP60, a molecular chaperone that resides mainly in mitochondria, could also regulate early erythropoiesis. In this study, we used Ti…
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