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2,170 results
  • CRISPR-engineered T cells in patients with refractory cancer. [Journal Article]
    Science 2020Stadtmauer EA, Fraietta JA, … June CH
  • CRISPR-Cas9 gene editing provides a powerful tool to enhance the natural ability of human T cells to fight cancer. We report a first-in-human phase I clinical trial to test the safety and feasibility of multiplex CRISPR-Cas9 editing to engineer T cells in three patients with refractory cancer. Two genes encoding the endogenous T cell receptor (TCR) chains, TCRα (TRAC) and TCRβ (TRBC) were deleted…
  • Entropy-Stabilized Oxides owning Fluorite Structure obtained by Hydrothermal Treatment. [Journal Article]
    Materials (Basel) 2020; 13(3)Spiridigliozzi L, Ferone C, … Dell'Agli G
  • Entropy-Stabilized Oxides (ESO) is a modern class of multicomponent advanced ceramic materials with attractive functional properties. Through a five-component oxide formulation, the configurational entropy is used to drive the phase stabilization over a reversible solid-state transformation from a multiphase to a single-phase state. In this paper, a new transition metal/rare earth entropy-stabili…
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