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(essential medicine)
152,525 results
  • The endocannabinoid system: Novel targets for treating cancer induced bone pain. [Review]
    Biomed Pharmacother 2019; 120:109504Sun J, Zhou YQ, … Ye DW
  • Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence suggested the endocannabinoid system (ECS) may play essential roles in CIBP. Here, we summarized the current understanding of the antinociceptive mechanisms of endocannabinoids in CIBP and discussed the beneficial effects of endo…
  • FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function. [Journal Article]
    Brain Res Bull 2019Chen P, Bing X, … Li BY
  • Hypertension is a common complication of metabolic abnormalities associated with cardiovascular system and characterized by sexual dimorphism in mammals. Fibroblast growth factor-21 (FGF-21) plays a critical role in metabolic-disorder related hypertension through the afferent loop of baroreflex. However, the gender difference in FGF-21-mediated blood pressure (BP) regulation via sexual dimorphic …
  • Can we 'seize' the gut microbiota to treat epilepsy? [Review]
    Neurosci Biobehav Rev 2019De Caro C, Iannone LF, … Russo E
  • The gut-microbiota, the complex intestinal microbial ecosystem essential to health, is an emerging concept in medicine. Several studies demonstrate a microbiota-gut-brain bidirectional connection via neural, endocrine, metabolic and immune pathways. Accordingly, the gut microbiota has a crucial role in modulating intestinal permeability, to alter local/peripheral immune responses and in productio…
  • Isolation and RNA purification of macrophages/microglia from the adult mouse spinal cord. [Journal Article]
    J Immunol Methods 2019; :112678Tsatas O, Ghasemlou N
  • The isolation of a highly pure and healthy population of macrophages from the CNS in a short time is essential for studying the role of these cells in injury and disease. Current methods rely either on the use of gradients and/or sorting, processes that result either in impure, reduced viability and/or altered populations of cells. Furthermore, RNA extraction after immunopanning is often difficul…
  • Neural-respiratory inflammasome axis in traumatic brain injury. [Review]
    Exp Neurol 2019; :113080Kerr N, de Rivero Vaccari JP, … Keane RW
  • Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. Approximately 20-25% of TBI subjects develop Acute Lung Injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Currently, mechanical ventilation is the only therapeutic intervention for TBI-induced lung injury. Our recent studies have shown that the inflammasome plays an important role in the syst…
  • A Novel Pathogenic CALR Exon 9 Mutation in a Patient with Essential Thrombocythemia. [Journal Article]
    Lab Med 2019Lee JS, Kim HY, … Lee YK
  • The clinical phenotypes and prognoses of CALR-mutant myeloproliferative neoplasms depend on the mutation type. The 2 most common mutations, type 1 (52-bp deletion) and type 2 (5-bp insertion), account for 85% of CALR-mutated neoplasms. The former confers a myelofibrotic phenotype, and the latter is associated with a low risk of thrombosis and an indolent clinical course. Individual case reports f…
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