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2,371 results
  • Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents. [Journal Article]
    Methods Mol Biol 2019; 1866:83-94Hoffman RM, Stern PH
  • The elevated methionine (MET) requirement for the growth of tumors, first observed by Sugimura in 1959, termed MET dependence, is a potentially highly effective therapeutic target. Proof of this principle is that when MET restriction (MR) was initially established in co-cultures of cancer and normal cells, MET dependence could be exploited to selectively kill cancer cells without killing co-cultu…
  • Genetic Lineage Tracing of Biliary Epithelial Cells. [Journal Article]
    Methods Mol Biol 2019; 1905:45-57Rubio-Tomás T, Aguilar-Bravo B, Sancho-Bru P
  • Lineage tracing of liver cells is a powerful tool to understand liver embryonic development, healthy liver cell homeostasis, tissue repair, and regeneration. Lineage tracing of biliary epithelial cells (BECs) in the adult liver has been used to assess the contribution of the biliary epithelium to liver injury, regeneration, and disease. These studies have shown the contribution of BECs to the exp…
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