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571 results
  • PCSK9 inhibitors and cardiovascular outcomes. [Journal Article]
    Expert Opin Biol Ther 2019Steffens D, Bramlage P, … Rauch-Kröhnert U
  • Introduction: Dyslipidemia, particularly elevated low-density lipoprotein cholesterol (LDL-C), is a key risk factor for atherosclerotic cardiovascular disease (ASCVD), and lipid-lowering drugs are beneficial for the primary and secondary prevention of cardiovascular (CV) disease. While statins are clear first-line drugs, new drug developments such as proprotein convertase subtilisin/kexin type 9 …
  • Dyslipidemia Management in Adults With Diabetes. [Review]
    Can J Diabetes 2019Lazarte J, Hegele RA
  • Lipid abnormalities beyond elevated low-density lipoprotein (LDL) cholesterol contribute to increased risk of atherosclerotic cardiovascular disease (ASCVD) in type 2 diabetes. We searched for English language randomized controlled trials of lipid-lowering therapies primarily since 2012 that included patients with diabetes. Diet and lifestyle advice are always a starting point for ASCVD preventio…
  • Dyslipidaemias and cardiovascular disease: Focus on the role of PCSK9 inhibitors [Journal Article]
    Curr Med Chem 2019Panagiotopoulou O, Chiesa ST, … Charakida M
  • Genetic, experimental and clinical studies have consistently confirmed that inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) can result in significant LDL-C lowering and two fully human PCSK9 mononclonal antibodies have received regulatory approval for use in high-risk patients. Co- administration of PCSK9 with statins has resulted in extremely low LDL-C levels with excellent s…
  • An update on pharmacotherapies in diabetic dyslipidemia. [Review]
    Prog Cardiovasc Dis 2019Gupta M, Tummala R, … Deedwania P
  • Hyperlipidemia plays a crucial role in the underlying pathogenesis of multiple cardiovascular diseases (CVD), including coronary artery disease, peripheral arterial disease, carotid stenosis, and heart failure. The risk of developing such diseases in the diabetic population is relatively high. Diabetes mellitus (DM) is an independent risk factor for premature atherosclerosis. The hallmark of DM d…
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