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35,011 results
  • Regulation of lifespan by neural excitation and REST. [Journal Article]
    Nature 2019; 574(7778):359-364Zullo JM, Drake D, … Yankner BA
  • The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or…
  • Hippocampal epileptogenesis in autoimmune encephalitis. [Journal Article]
    Ann Clin Transl Neurol 2019Romoli M, Krashia P, … Calabresi P
  • CONCLUSIONS: Using patient CSF, we have demonstrated that the AE-associated antibodies against LGI1 and CASPR2 are able to increase hippocampal CA1 neuron excitability, facilitating epileptiform activity. These findings provide in vivo pathogenic insights into neuronal dysfunction in these conditions.
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