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380,711 results
  • Engineered Extracellular Vesicles and Their Mimetics for Clinical Translation. [Review]
    Methods 2019Kim H, Kim D, … Lee JB
  • Cells secrete extracellular vesicles (EVs) to external environments to achieve cellular homeostasis and cell-to-cell communication. Their therapeutic potential has been constantly spotlighted since they mirror both cytoplasmic and membranous components of parental cells. Meanwhile, growing evidence suggests that EV engineering could further promote EVs with a maximized capacity. In this review, a…
  • Reverse-filtering on extracellular action potential for waveform analysis. [Journal Article]
    Neurosci Res 2019Mizuhiki T, Setogawa T, Shidara M
  • For further understanding the role of serotonergic neurons, unit recordings using behaving primates are increasingly needed. A widely used criterion to identify serotonergic neuron relies on the duration of extracellular action potential (EAP). However, the duration is inaccurate due to the passband limitation needed to carry out the spike sorting. To restore an original waveform, we conducted 1)…
  • Glia-derived exosomes: Promising therapeutic targets. [Review]
    Life Sci 2019; :116951Li H, Luo Y, … Liu J
  • Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both …
  • Neural-respiratory inflammasome axis in traumatic brain injury. [Review]
    Exp Neurol 2019; :113080Kerr N, de Rivero Vaccari JP, … Keane RW
  • Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. Approximately 20-25% of TBI subjects develop Acute Lung Injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Currently, mechanical ventilation is the only therapeutic intervention for TBI-induced lung injury. Our recent studies have shown that the inflammasome plays an important role in the syst…
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