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9,323 results
  • MYCN amplification drives an aggressive form of spinal ependymoma. [Journal Article]
    Acta Neuropathol 2019Ghasemi DR, Sill M, … Pajtler KW
  • Spinal ependymal tumors form a histologically and molecularly heterogeneous group of tumors with generally good prognosis. However, their treatment can be challenging if infiltration of the spinal cord or dissemination throughout the central nervous system (CNS) occurs and, in these cases, clinical outcome remains poor. Here, we describe a new and relatively rare subgroup of spinal ependymal tumo…
  • Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms. [Review]
    Semin Cancer Biol 2019Valent P, Sadovnik I, … Schumacher U
  • The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis. Sometimes, extra-medullary organ invasion shows a metastasis-like or even sarcoma-like destructi…
  • Cardiac chloroma or cardiac myeloid sarcoma: Case Report. [Journal Article]
    Echocardiography 2019Abdelnabi MH, Almaghraby A, … ElSharkawy E
  • Chloroma or myeloid sarcoma is rare extramedullary tumor composed of immature myeloid cells that may occur in association with or during or even before the course of adult myelodysplastic or myeloproliferative diseases. It may involve different organs including the orbit, skin, lymph nodes, bone, gastrointestinal tract, breast, central nervous system, and lung. Cardiac involvement with MS is an e…
  • Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. [Journal Article]
    Blood Adv 2019; 3(15):2355-2367Hsu YC, Chen TC, … Tien HF
  • Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, a congenital neurodevelopmental disorder. Loss-of-function mutations of PHF6 are detected in patients with acute leukemia, mainly of T-cell lineage and in a small proportion of myeloid lineage. The functions …
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