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1,342 results
  • Condensin: The Little Motor Protein that Could. [Journal Article]
    Mol Cell. 2020 Jul 02; 79(1):3-5.Goloborodko A
  • Kong et al. (2020) present the low-resolution structure of the ATPɣS-bound human condensin I and II complexes and demonstrate that human condensins can extrude DNA loops in a symmetric and asymmetric fashion and compact nucleosome-bound DNA.
  • Carbon Nanotube Reinforced High Density Polyethylene Materials for Offshore Sheathing Applications. [Journal Article]
    Molecules. 2020 Jun 27; 25(13)Okolo C, Rafique R, … Inam F
  • Multiwall carbon nanotube (CNT)-filled high density polyethylene (HDPE) nanocomposites were prepared by extrusion and considered for their suitability in the offshore sheathing applications. Transmission electron microscopy was conducted to analyse dispersion after bulk extrusion. Monolithic and nanocomposite samples were subjected to accelerated weathering and photodegradation (carbonyl and viny…
  • Development of High-Moisture Meat Analogues with Hemp and Soy Protein Using Extrusion Cooking. [Journal Article]
    Foods. 2020 Jun 11; 9(6)Zahari I, Ferawati F, … Purhagen JK
  • The interest in plant-based products is growing in Western countries, mostly due to health and environmental issues that arise from the consumption and production of animal-based food products. Many vegan products today are made from soy, but drawbacks include the challenges of cultivating soy in colder climates such as northern Europe. Therefore, the present study investigates whether industrial…
  • Loop extrusion: theory meets single-molecule experiments. [Review]
    Curr Opin Cell Biol. 2020 Jun 10; 64:124-138.Banigan EJ, Mirny LA
  • Chromosomes are organized as chromatin loops that promote segregation, enhancer-promoter interactions, and other genomic functions. Loops were hypothesized to form by 'loop extrusion,' by which structural maintenance of chromosomes (SMC) complexes, such as condensin and cohesin, bind to chromatin, reel it in, and extrude it as a loop. However, such exotic motor activity had never been observed. F…
  • RSU-1 Maintains Integrity of Caenorhabditis elegans Vulval Muscles by Regulating α-actinin. [Journal Article]
    G3 (Bethesda). 2020 May 27 [Online ahead of print]Wang X, Huang S, … Tse YC
  • Egg-laying behavior in Caenorhabditis elegans is a well-known model for investigating fundamental cellular processes. In egg-laying, muscle contraction is the relaxation of the vulval muscle to extrude eggs from the vulva. Unlike skeletal muscle, vulval muscle lacks visible striations of the sarcomere. Therefore, vulval muscle must counteract the mechanical stress, caused by egg extrusion and bod…
  • The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes. [Journal Article]
    Nat Commun. 2020 May 25; 11(1):2598.ElInati E, Zielinska AP, … Turner JMA
  • DNA double-strand breaks (DSBs) are toxic to mammalian cells. However, during meiosis, more than 200 DSBs are generated deliberately, to ensure reciprocal recombination and orderly segregation of homologous chromosomes. If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise viability in offspring. Oocytes in which DSBs persist are therefore eliminated by the DNA-damage ch…
  • Cohesin and condensin extrude DNA loops in a cell-cycle dependent manner. [Journal Article]
    Elife. 2020 May 12; 9Golfier S, Quail T, … Brugués J
  • Loop extrusion by structural maintenance of chromosomes complexes (SMCs) has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and it is unknown whether loop extrusion dynamics and the complexes that extrude DNA also differ. Here, we used Xenopus egg extracts to reconstitut…
  • Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice. [Journal Article]
    J Pharmacol Exp Ther. 2020 Apr 28 [Online ahead of print]Torrens A, Vozella V, … Piomelli D
  • We investigated the pharmacokinetic properties of Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive constituent of cannabis, in adolescent and adult male mice. The drug was administered at logarithmically ascending doses (0.5, 1.6 and 5 mg/kg, intraperitoneal) to pubertal adolescent (37-day old) and adult (70-day old) mice. Δ9-THC and its first-pass metabolites - 11-hydroxy-Δ9-THC (11-OH-TH…
  • Physiology and Medical Treatments for Alopecia. [Review]
    Facial Plast Surg Clin North Am. 2020 May; 28(2):149-159.Tai T, Kochhar A
  • Androgenetic alopecia (AGA) is the most common hair loss disorder in men and women. The characteristic and reproducible balding pattern in AGA negatively affects self-image and the external perceptions of the balding patient. The phenotypical changes are driven by dihydrotestosterone (DHT) and its precursor testosterone. DHT induces follicle miniaturization and hair cycle changes until resulting …
  • Chromosome organization by one-sided and two-sided loop extrusion. [Journal Article]
    Elife. 2020 Apr 06; 9Banigan EJ, van den Berg AA, … Mirny LA
  • SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops. Modeling assuming two-sided loop extrusion reproduces key features of chromatin organization across different organisms. In vitro single-molecule experiments confirmed that yeast condensins extrude…
  • A novel waterborne polyurethane with biodegradability and high flexibility for 3D printing. [Journal Article]
    Biofabrication. 2020 May 12; 12(3):035015.Feng Z, Wang D, … Jiang H
  • Three-dimensional (3D) printing provides a new approach of fabricating implantable products because it permits a flexible manner to extrude complex and customized shapes of the tissue scaffolds. Compared with other printable biomaterials, the polyurethane elastomer has several merits, including excellent mechanical properties and good biocompatibility. However, some intrinsic behavior, especially…
  • DNA-loop extruding condensin complexes can traverse one another. [Journal Article]
    Nature. 2020 03; 579(7799):438-442.Kim E, Kerssemakers J, … Dekker C
  • Condensin, a key component of the structure maintenance of chromosome (SMC) protein complexes, has recently been shown to be a motor that extrudes loops of DNA1. It remains unclear, however, how condensin complexes work together to collectively package DNA into chromosomes. Here we use time-lapse single-molecule visualization to study mutual interactions between two DNA-loop-extruding yeast conde…
  • Sequence and structural determinants of ligand-dependent alternating access of a MATE transporter. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4732-4740.Jagessar KL, Claxton DP, … Mchaourab HS
  • Multidrug and toxic compound extrusion (MATE) transporters are ubiquitous ion-coupled antiporters that extrude structurally and chemically dissimilar cytotoxic compounds and have been implicated in conferring multidrug resistance. Here, we integrate double electron-electron resonance (DEER) with functional assays and site-directed mutagenesis of conserved residues to illuminate principles of liga…
  • Reactions in Water Involving the "On-Water" Mechanism. [Review]
    Chemistry. 2020 Feb 14 [Online ahead of print]Kitanosono T, Kobayashi S
  • Ever-evolving catalyst advances in synthetic protocols using water as a reaction medium have enriched the understanding of sustainable organic chemistry. Because conventional classification and definitions were ambivalent, it is proposed here that catalytic reactions using water be collectively called to be "in water", with further classification into seven types. When accelerated in water as het…
  • Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters. [Journal Article]
    J Antimicrob Chemother. 2020 May 01; 75(5):1135-1139.Foong WE, Wilhelm J, … Pos KM
  • CONCLUSIONS: TetA plays an important role in tigecycline efflux of A. baumannii by removing the drug from cytoplasm to periplasm and, subsequently, the RND-type transporters AdeABC and AdeIJK extrude tigecycline across the outer membrane. When challenged with tigecycline, tetA is up-regulated in A. baumannii AYE. Synergy between TetA and the RND-type transporters AdeABC and/or AdeIJK appears necessary for A. baumannii to confer higher tigecycline resistance via drug efflux.
  • Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. [Journal Article]
    J Exp Med. 2020 Apr 06; 217(4)Ricardo-Gonzalez RR, Schneider C, … Locksley RM
  • Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells prominent at barrier sites. Although precursors are found in blood, mature ILC2s can enter the circulation after small intestinal perturbation by migratory helminths and move to distant tissues to influence the local reparative response. Using fate-mapping and methods to bypass the lung or intestinal phases of Nippostrongylus brasili…
  • Antibiotic Drug Nanocarriers for Probing of Multidrug ABC Membrane Transporter of Bacillus subtilis. [Journal Article]
    ACS Omega. 2020 Jan 28; 5(3):1625-1633.Cherukuri PK, Songkiatisak P, … Xu XN
  • Multidrug membrane transporters can extrude a wide range of substrates, which cause multidrug resistance and ineffective treatment of diseases. In this study, we used three different sized antibiotic drug nanocarriers to study their size-dependent inhibitory effects against Bacillus subtilis. We functionalized 2.4 ± 0.7, 13.0 ± 3.1, and 92.6 ± 4.4 nm silver nanoparticles (Ag NPs) with a monolayer…
  • A Robotic Biopsy Endoscope with Magnetic 5-DOF Locomotion and a Retractable Biopsy Punch. [Journal Article]
    Micromachines (Basel). 2020 Jan 17; 11(1)Hoang MC, Le VH, … Kim CS
  • Capsule endoscopes (CEs) have emerged as an advanced diagnostic technology for gastrointestinal diseases in recent decades. However, with regard to robotic motions, they require active movability and multi-functionalities for extensive, untethered, and precise clinical utilization. Herein, we present a novel wireless biopsy CE employing active five degree-of-freedom locomotion and a biopsy needle…
  • ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas. [Review]
    Pharmaceutics. 2019 Dec 23; 12(1)Gomez-Zepeda D, Taghi M, … Menet MC
  • Drug delivery into the brain is regulated by the blood-brain interfaces. The blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the blood-arachnoid barrier (BAB) regulate the exchange of substances between the blood and brain parenchyma. These selective barriers present a high impermeability to most substances, with the selective transport of nutrients and transporters …
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