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3,369 results
  • Cardiovascular prevention: Frontiers in lipid guidelines. [Journal Article]
    Clin Med (Lond) 2020; 20(1):36-42Kim EJ, Wierzbicki AS
  • Cardiovascular disease (CVD) remains one of the principal causes of morbidity and mortality in the world. International guidelines are being updated to take into account new evidence and improved health economics as drug patents expire. Recent studies have investigated the best lipid fractions to predict CVD, suggested additional CVD risk factors and a potential role for novel biomarkers while bi…
  • [Approach to Patients with Statin Intolerance: Evidence-Based Review]. [Review]
    Acta Med Port 2020; 33(1):49-57Almeida JT, Esteves AL, … Palma I
  • CONCLUSIONS: The strategies proposed by the different studies vary according to the severity of symptoms of intolerance including maintenance of the statin therapy (dose reduction, addition of a statin of equal or lower intensity or alternate days' uptake) and lipid-lowering therapy with other drugs (ezetimibe monotherapy or association with statin tolerated dose). Supplementation with coenzyme Q10 or vitamin D, in order to improve adherence to treatment with statins, is not recommended.This review highlights some alternatives to address patients' intolerance to statins; however, these are mostly based on recommendations with low to moderate evidence. Therefore, further research with randomized studies involving greater number of patients is required, in order to obtain a more robust recommendation.
  • Current and future trends in the treatment of dyslipidemias. [Journal Article]
    Vnitr Lek 2019; 65(10):643-650Vrablík M
  • Lipid-lowering treatment is a part of prevention and treatment of vascular diseases caused by atherosclerosis. We need new strategies for modifying plasma lipoprotein levels in the light of new findings that reduce target lipid levels further lower, as well as the growing population of patients for whom existing treatments cannot be offered. The spectrum of existing drugs (new statins) is widenin…
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