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3,281 results
  • Prolonged acidosis is a feature of SGLT2i-induced euglycaemic diabetic ketoacidosis. [Journal Article]
    Endocrinol Diabetes Metab Case Rep 2019; 2019Rafey MF, Butt A, … Finucane FM
  • We describe two cases of SGLT2i-induced euglycaemic diabetic ketoacidosis, which took longer than we anticipated to treat despite initiation of our DKA protocol. Both patients had an unequivocal diagnosis of type 2 diabetes, had poor glycaemic control with a history of metformin intolerance and presented with relatively vague symptoms post-operatively. Neither patient had stopped their SGLT2i pre…
  • PCSK9 inhibitors and cardiovascular outcomes. [Journal Article]
    Expert Opin Biol Ther 2019; :1-13Steffens D, Bramlage P, … Rauch-Kröhnert U
  • Introduction: Dyslipidemia, particularly elevated low-density lipoprotein cholesterol (LDL-C), is a key risk factor for atherosclerotic cardiovascular disease (ASCVD), and lipid-lowering drugs are beneficial for the primary and secondary prevention of cardiovascular (CV) disease. While statins are clear first-line drugs, new drug developments such as proprotein convertase subtilisin/kexin type 9 …
  • Niemann-Pick C1-like 1 Promotes Intestinal Absorption of Siphonaxanthin. [Journal Article]
    Lipids 2019Manabe Y, Ichihara M, … Sugawara T
  • Siphonaxanthin is a carotenoid found in certain green algae, and its promising beneficial properties, such as its anti-obesity effect, have recently been demonstrated. However, there is little information about the molecular mechanisms underlying intestinal absorption of siphonaxanthin. In this study, we aimed to elucidate how siphonaxanthin is transported across the intestinal epithelium using d…
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