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(factor ix human )
9,372 results
  • The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. [Journal Article]
    PLoS Genet 2019; 15(9):e1008379Misslinger M, Scheven MT, … Haas H
  • Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing in this fungus. Our studies revealed that (i) GrxD is essential for growth; (ii) expression of the encoding gene, grxD, is repressed by the transcript…
  • Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue. [Journal Article]
    Blood Adv 2019; 3(17):2668-2678Jankowski W, McGill J, … Sauna ZE
  • Vatreptacog alfa (VA), a recombinant activated human factor VII (rFVIIa) variant with 3 amino acid substitutions, was developed to provide increased procoagulant activity in hemophilia patients with inhibitors to factor VIII or factor IX. In phase 3 clinical trials, changes introduced during the bioengineering of VA resulted in the development of undesired anti-drug antibodies in some patients, l…
  • Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates. [Journal Article]
    Blood Adv 2019; 3(17):2632-2641Salas D, Kwikkers KL, … Ferreira V
  • Adeno-associated virus (AAV)-based liver gene therapy has been shown to be clinically successful. However, the presence of circulating neutralizing antibodies (NABs) against AAV vector capsids remains a major challenge as it may prevent successful transduction of the target cells. Therefore, there is a need to develop strategies that would enable AAV-mediated gene delivery to patients with preexi…
  • A large deletion in the GP9 gene in Cocker Spaniel dogs with Bernard-Soulier syndrome. [Journal Article]
    PLoS One 2019; 14(9):e0220625Gentilini F, Turba ME, … Drögemüller C
  • Inherited bleeding disorders including abnormalities of platelet number and function rarely occur in a variety of dog breeds, but are probably underdiagnosed. Genetically characterized canine forms of platelet disorders provide valuable large animal models for understanding similar platelet disorders in people. Breed-specific disease associated genetic variants in only eight different genes are k…
  • [Liver transplantation in hemophilia A. Report of one case]. [Case Reports]
    Rev Med Chil 2019; 147(3):378-383Benítez C, Zúñiga P, … Martínez J
  • Due to blood derivative requirements, many patients with hemophilia were exposed to Hepatitis C virus infection (HCV) before the availability of HCV testing. We report a 46-year-old male with Hemophilia A with a hepatitis virus C infection since 2004 causing a cirrhosis. Due to a hepatopulmonary syndrome, he received a liver allograph using a factor VIII replacement protocol, after eradicating th…
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