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(factor ix human )
9,587 results
  • WFH State-of-the-art paper 2020: In vivo lentiviral vector gene therapy for haemophilia. [Review]
    Haemophilia. 2020 Jun 14 [Online ahead of print]Cantore A, Naldini L
  • Over the last decade, the development of new treatments for haemophilia has progressed at a very rapid pace. Despite all the promising advances in protein products, the prospect offered by gene therapy of a single potentially lifelong treatment remains attractive for people with haemophilia. Transfer to the liver of coagulation factor VIII (FVIII) or factor IX (FIX) transgenes has indeed the pote…
  • Whole-body heat exposure causes developmental stage-specific apoptosis of male germ cells. [Journal Article]
    Mol Reprod Dev. 2020 Jun 07 [Online ahead of print]Yoon J, Rhee K
  • Humans are occasionally exposed to extreme environmental heat for a prolonged period of time. Here, we investigated testicular responses to whole-body heat exposure by placing mice in a warm chamber. Among the examined tissues, the testis was found to be most susceptible to heat stress. Heat stress induces direct responses within germ cells, such as eukaryotic initiation factor 2α phosphorylation…
  • Effect of Carbonic Anhydrase IX inhibitors on human endothelial cell survival. [Journal Article]
    Pharmacol Res. 2020 May 30; 159:104964.Genah S, Angeli A, … Morbidelli L
  • The vascular endothelium is one of the first barriers encountered by drugs and xenobiotics, which, once administered, enter the blood stream and diffuse to all organs through blood vessels. The continuous exposure of endothelial cells to drugs and chemical compounds turns out to be a huge risk for the cardiovascular system, as these substances could compromise endothelial vitality and function an…
  • Uncertainty in an era of transformative therapy for haemophilia: Addressing the unknowns. [Journal Article]
    Haemophilia. 2020 Jun 02 [Online ahead of print]Pierce GF
  • Haemophilia is at the dawn of a new era in therapeutic management, one that can generate greater protection from bleeding and a functional cure in some individuals. Prior advances in protein engineering and monoclonal antibody technology have facilitated therapeutic options to maintain decreased risk of bleeding and less burdensome treatment. The use of gene transfer, first proposed in 1971 for m…
  • Laboratory issues in gene therapy and emicizumab. [Review]
    Haemophilia. 2020 May 29 [Online ahead of print]Bowyer AE, Lowe AE, Tiefenbacher S
  • The treatment options for the haemostatic disorders, haemophilia A and haemophilia B, have progressed rapidly over the last decade. The introduction of extended half-life recombinant factor VIII (FVIII) and factor IX (FIX) concentrates to replace these missing clotting factors highlighted discordance between one-stage activated partial thromboplastin time (APTT)-based clotting factor assays and c…
  • Identification of novel glycosylation events on human serum-derived factor IX. [Journal Article]
    Glycoconj J. 2020 May 06 [Online ahead of print]Pegg CL, Zacchi LF, … Schulz BL
  • Human Factor IX is a highly post-translationally modified protein that is an important clotting factor in the blood coagulation cascade. Functional deficiencies in Factor IX result in the bleeding disorder haemophilia B, which is treated with plasma-derived or recombinant Factor IX concentrates. Here, we investigated the post-translational modifications of human serum-derived Factor IX and report…
  • Human Serum Albumin Facilitates Heme-Iron Utilization by Fungi. [Journal Article]
    mBio. 2020 Apr 21; 11(2)Pinsky M, Roy U, … Kornitzer D
  • A large portion of biological iron is found in the form of an iron-protoporphyrin IX complex, or heme. In the human host environment, which is exceptionally poor in free iron, heme iron, particularly from hemoglobin, constitutes a major source of iron for invading microbial pathogens. Several fungi were shown to utilize free heme, and Candida albicans, a major opportunistic pathogen, is able both…
  • Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin. [Journal Article]
    Oncogenesis. 2020 Apr 14; 9(4):39.Liu Z, Ge R, … Mao J
  • Enhanced migration is pivotal for the malignant development of glioblastoma (GBM), but the underlying molecular mechanism that modulates the migration of the GBM cells remains obscure. Here we show that nuclear factor IX (NFIX) is significantly upregulated in human GBM lesions compared with normal or low-grade gliomas. NFIX deficiency impairs the migration of GBM cells and inhibits the tumor grow…
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