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77,204 results
  • Gray matter changes related to microglial activation in Alzheimer's disease. [Journal Article]
    Neurobiol Aging. 2020 Jun 17; 94:236-242.Nicastro N, Malpetti M, … O'Brien JT
  • Neuroinflammation is increasingly recognized as playing a key pathogenetic role in Alzheimer's disease (AD). We examined the relationship between in vivo neuroinflammation and gray matter (GM) changes. Twenty-eight subjects with clinically probable AD (n = 14) and amyloid-positive mild cognitive impairment (n = 14) (age 71.9 ± 8.4 years, 46% female) and 24 healthy controls underwent structural 3T…
  • TRACE: transcription factor footprinting using chromatin accessibility data and DNA sequence. [Journal Article]
    Genome Res. 2020 Jul 06 [Online ahead of print]Ouyang N, Boyle AP
  • Transcription is tightly regulated by cis-regulatory DNA elements where transcription factors can bind. Thus, identification of transcription factor binding sites (TFBSs) is key to understanding gene expression and whole regulatory networks within a cell. The standard approaches used for TFBS prediction, such as position weight matrices (PWMs) and chromatin immunoprecipitation followed by sequenc…
  • A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Fragile X Syndrome. [Journal Article]
    Pediatr Neurol. 2020 May 23 [Online ahead of print]Berry-Kravis E, Horrigan JP, … Jones NE
  • CONCLUSIONS: Trofinetide was well tolerated in adolescent and adult males with fragile X syndrome. Despite the relatively short duration of the study, a consistent signal of efficacy at the higher dose was observed in both caregiver and clinician assessments, based on a novel analytical model incorporating evaluation of multiple key symptom areas of fragile X syndrome. This finding suggests a potential for trofinetide treatment to provide clinically meaningful improvement in core fragile X syndrome symptoms.
  • [Choosing wisely - perspectives: what are the key questions?] [Journal Article]
    Z Gastroenterol. 2020 Jul; 58(7):652-658.Holstege A
  • Gastroenterology offers a wide field for future "choosing wisely" recommendations (CWR). They should refer not only to an under- or overuse of diagnostic tools like laboratory or imaging tests but also to an evidence-based application of drug therapies und endoscopic interventions. Drugs like antibiotics or proton pump inhibitors are both often prescribed in the absence of clearly defined underly…
  • First results of a national external quality assessment scheme for the detection of SARS-CoV-2 genome sequences. [Journal Article]
    J Clin Virol. 2020 Jul 06; 129:104537.Görzer I, Buchta C, … Aberle SW
  • CONCLUSIONS: A total of 52 laboratories participated, contributing results from 67 test panels comprising 42 distinct combinations of NA extraction and PCR reagents. By testing 3 positive (CT values: S1, 28.4; S2, 33.6; S3, 38.5) and 1 negative sample, no false-positive results were obtained by any of the laboratories. Otherwise, 40/67 tests (60 %) detected all positive samples correctly as positive, but 25/67 tests (37 %) did not detect the weakest positive sample (S3), and 3 % reported S2 and S3 as false-negative. Improvement in test sensitivity by focusing on NA extraction and/or PCR-based detection is recommended.
  • THE RISK OF THYROID CANCER IN PATIENTS WITH THYROID NODULE 3 CM OR LARGER. [Journal Article]
    Endocr Pract. 2020 Jul 13 [Online ahead of print]Kornelius E, Lo SC, … Yang YS
  • Objectives: There are conflicting data on the risk of thyroid cancer in thyroid nodules 3 cm or larger, and few such studies on this issue have been conducted in Asia. This study aimed to examine the risk of thyroid cancer in patients with thyroid nodules 3 cm or larger. Methods: This was a seven-year retrospective study conducted in a tertiary referral hospital in Taiwan. All patients with a t…
  • Benchmarking gene ontology function predictions using negative annotations. [Journal Article]
    Bioinformatics. 2020 Jul 01; 36(Supplement_1):i210-i218.Warwick Vesztrocy A, Dessimoz C
  • With the ever-increasing number and diversity of sequenced species, the challenge to characterize genes with functional information is even more important. In most species, this characterization almost entirely relies on automated electronic methods. As such, it is critical to benchmark the various methods. The Critical Assessment of protein Function Annotation algorithms (CAFA) series of communi…
  • Weighted minimizer sampling improves long read mapping. [Journal Article]
    Bioinformatics. 2020 Jul 01; 36(Supplement_1):i111-i118.Jain C, Rhie A, … Phillippy AM
  • In this era of exponential data growth, minimizer sampling has become a standard algorithmic technique for rapid genome sequence comparison. This technique yields a sub-linear representation of sequences, enabling their comparison in reduced space and time. A key property of the minimizer technique is that if two sequences share a substring of a specified length, then they can be guaranteed to ha…
  • Re-positive Cases of Nucleic Acid Tests in Discharged Patients With COVID-19: A Follow-Up Study. [Journal Article]
    Front Med (Lausanne). 2020; 7:349.Qiao XM, Xu XF, … Wang X
  • Background: The frequent emergence of the re-positive patients with COVID-19 is a potential threat worldwide. This study aimed to describe data from admission to follow-up for patients with COVID-19 and analyze the possible causes for re-positive nucleic acid tests to provide more scientific basis for reducing the numbers of re-positive patients after discharge. Methods: We retrospectively reco…
  • Detecting prostate cancer using deep learning convolution neural network with transfer learning approach. [Journal Article]
    Cogn Neurodyn. 2020 Aug; 14(4):523-533.Abbasi AA, Hussain L, … Chaudhary QA
  • Prostate Cancer in men has become one of the most diagnosed cancer and also one of the leading causes of death in United States of America. Radiologists cannot detect prostate cancer properly because of complexity in masses. In recent past, many prostate cancer detection techniques were developed but these could not diagnose cancer efficiently. In this research work, robust deep learning convolut…
  • Clinicopathologic Significance of False-Positive Lymph Node Status on FDG-PET in Lung Cancer. [Journal Article]
    Clin Lung Cancer. 2020 May 14 [Online ahead of print]Endoh H, Yamamoto R, … Oriuchi N
  • CONCLUSIONS: Metastatic lymph nodes show higher FDG uptake than false-positive lymph nodes, and older patient age, bilateral hilar FDG uptake, and no swollen nodes are associated with no metastases. Patients with lymph node metastases have worse survival than those with false-positive FDG-PET findings. However, abnormal FDG uptake in the lymph node is an important prognostic factor.
  • Five-year outcomes of endovascular repair of complicated acute type B aortic dissections. [Journal Article]
    J Thorac Cardiovasc Surg. 2020 May 13 [Online ahead of print]Bavaria JE, Brinkman WT, … White RA
  • CONCLUSIONS: In the Dissection Trial, patients experienced positive and sustained measures of aortic remodeling. Survival outcomes, need for secondary procedures, and adverse event rates were consistent with previous thoracic endovascular aortic repair studies. Although limitations exist with the follow-up compliance, the Valiant Captivia thoracic stent graft system was effective in the long-term management of acute complicated type B aortic dissections in this patient population with a challenging condition.
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