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146,491 results
  • Characterization and genome analysis of B1 sub-cluster mycobacteriophage PDRPxv. [Journal Article]
    Virus Res 2020; :197884Sinha A, Eniyan K, … Bajpai U
  • Mycobacteriophages are viruses specific to mycobacteria that have gained attention as alternative therapeutic strategies for treating antibiotic-resistant infections. Mycobacteriophages are highly diverse and have been grouped into 29 clusters, 63 sub-clusters and 10 singletons based on the genome sequence. Here, we annotate the genome of PDRPxv, a lytic mycobacteriophage isolated from New Delhi;…
  • RASSF1A: A promising target for the diagnosis and treatment of cancer. [Review]
    Clin Chim Acta 2020Bin Y, Ding Y, … Liao A
  • The Ras association domain family 1 isoform A (RASSF1A), a tumor suppressor, regulates several tumor-related signaling pathways and interferes with diverse cellular processes. RASSF1A is frequently demonstrated to be inactivated by hypermethylation in numerous types of solid cancers. It is also associated with lymph node metastasis, vascular invasion, and chemo-resistance. Therefore, reactivation…
  • Genetic cancer predisposition syndromes among older adults. [Review]
    J Geriatr Oncol 2020Chavarri-Guerra Y, Slavin TP, … Weitzel JN
  • Earlier age at onset is one characteristic of hereditary cancer syndromes, so most studies of genetic testing have focused on young patients with cancer. However, recent studies of multigene panel tests in unselected cancer populations have detected a considerable proportion of older patients with germline pathogenic variants (PVs) in cancer susceptibility genes. As the number of older patients w…
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