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(fasciculation)
2,047 results
  • Evolutionary conserved role of neural cell adhesion molecule-1 in memory. [Journal Article]
    Transl Psychiatry. 2020 Jul 06; 10(1):217.Vukojevic V, Mastrandreas P, … Stetak A
  • The neural cell adhesion molecule 1 (NCAM-1) has been implicated in several brain-related biological processes, including neuronal migration, axonal branching, fasciculation, and synaptogenesis, with a pivotal role in synaptic plasticity. Here, we investigated the evolutionary conserved role of NCAM-1 in learning and memory. First, we investigated sustained changes in ncam-1 expression following …
  • Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease. [Journal Article]
    Front Neurosci. 2020; 14:533.Rudnitskaya EA, Kozlova TA, … Kolosova NG
  • Aging is the major risk factor of the most common (∼95% of cases) sporadic Alzheimer's disease (AD). Accumulating data indicate middle age as a critical period for the relevant pathological processes, however, the question of when AD starts to develop remains open. It has been reported only recently that in the early postnatal period-when brain development is completing-preconditions for a decrea…
  • The role of the diencephalon in the guidance of thalamocortical axons in mice. [Journal Article]
    Development. 2020 Jun 15 [Online ahead of print]Quintana-Urzainqui I, Hernández-Malmierca P, … Price DJ
  • Thalamocortical axons (TCAs) cross several tissues on their journey to the cortex. Mechanisms must be in place along the route to ensure they connect with their targets in an orderly fashion. The ventral telencephalon acts as an instructive tissue, but the importance of the diencephalon in TCA mapping is unknown. We report that disruption of diencephalic development by Pax6 deletion results in a …
  • A Paralyzing Case of Myalgias. [Journal Article]
    Am J Case Rep. 2020 May 13; 21:e922568.Simard C, Paquin A, Schwartz BC
  • CONCLUSIONS: Succinylcholine remains a commonly used agent in anesthesia and succinylcholine-induced myalgia should remain in the differential diagnosis of acute, non-inflammatory myalgia. Its recognition can help avoid unwarranted, possibly invasive investigations and their associated additional healthcare costs.
  • 101 Amyotrophic Lateral Sclerosis (ALS) - Not Just a Motor Disease? Isolated Bitter and Sweet Taste Loss in ALS. [Journal Article]
    CNS Spectr. 2020 Apr; 25(2):266.Ashary AA, Patel DN, Hirsch AR
  • CONCLUSIONS: While Lang found no taste loss in ALS (Lang, 2011), Pelletier found reduction in intensity of taste to all modalities in different sectors of the tongue, but paradoxically demonstrated normogeusia in whole mouth taste perception (Pelletier, 2013). Pathological specimens of those with ALS revealed degeneration in the nucleus parabrachialis medialis and tractus trigeminothalamicus dorsalis (Oyanagi, 2015), suggesting that taste deficit may be due to central white matter abnormalities. Sweet taste is localized in the most posterior and rostral aspect of the right insular cortex, immediately adjacent to bitter (Prinster, 2017), suggesting a neighborhood effect phenomena. Weight loss in ALS may be due to sensory distortion and secondary impairment of appetite. It would be worthwhile to investigate those with ALS for evidence of otherwise overlooked gustatory deficits, correction of which may improve appetite and nutritional state.
  • Accidental injection of succinylcholine into epidural space as a test dose. [Case Reports]
    Saudi J Anaesth. 2020 Apr-Jun; 14(2):238-240.Toleska M, Naumovski F, Dimitrovski A
  • Inadvertent injection of nonepidural drugs into the epidural space is a rare situation, which is under-reported, and can lead to serious complications, such as cardiovascular and respiratory complications, paraplegia, or quadriplegia, and can worsen the patients' outcome from surgery. Succinylcholine administered epidurally leads to the appearance of fasciculation and shortness of breath and can …
  • Laryngeal electromyography in amyotrophic lateral sclerosis. [Journal Article]
    J Neurol Neurosurg Psychiatry. 2020 Apr 21 [Online ahead of print]Martins MP, de Lima FD, … França MC
  • CONCLUSIONS: LEMG is able to identify laryngeal denervation in patients with ALS, sometimes before clinical manifestations are noticed. This technique may be a useful diagnostic tool for selected patients with suspicion of ALS.
  • Myalgia in 30 Patients with Suspected Myopathy. [Journal Article]
    Int J Environ Res Public Health. 2020 04 06; 17(7)Lehmann Urban D, Lehmann E, … Kraya T
  • CONCLUSIONS: Only a weak correlation between pain intensity and pressure pain threshold has been suggested, which is concordant with our results. The hypothesis that high pain intensity levels are equivalent to high pain sensitivity levels was not demonstrated.
  • Facial myokymia in inherited peripheral nerve hyperexcitability syndrome. [Journal Article]
    Pract Neurol. 2020 May; 20(3):253-255.Camelo CG, Silva AMS, … Zanoteli E
  • Peripheral nerve hyperexcitability syndrome comprises a heterogeneous group of diseases, clinically characterised by myokymia, fasciculation, muscle cramps and stiffness. The causes are either immune mediated or non-immune mediated. Non-immune-mediated forms are mostly genetic, relating to two main genes: KCNQ2 and KCNA1 Patients with KCNQ2 gene mutations typically present with epileptic encephal…
  • TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation. [Journal Article]
    Cell Rep. 2020 Jan 28; 30(4):1164-1177.e7.Suter TACS, Blagburn SV, … Jaworski A
  • Neuronal migration, axon fasciculation, and axon guidance need to be closely coordinated for neural circuit assembly. Spinal motor neurons (MNs) face unique challenges during development because their cell bodies reside within the central nervous system (CNS) and their axons project to various targets in the body periphery. The molecular mechanisms that contain MN somata within the spinal cord wh…
  • Identification of muscle fasciculations from surface EMG: comparison with ultrasound-based detection. [Journal Article]
    Conf Proc IEEE Eng Med Biol Soc. 2019 07; 2019:5117-5120.Botter A, Carbonaro M, … Hodson-Tole E
  • The clinical standard for the identification of muscle fasciculations is needle electromyography. However, both surface electromyograms (sEMG) and ultrasound imaging (US) have been recently proposed as alternative and more sensitive approaches. The aims of this study were to: (i) compare the sensitivity to muscle fasciculations of sEMG and US, (ii) assess the rate of agreement (RoA) between the t…
  • Spontaneous continuous motor unit single discharges. [Journal Article]
    Muscle Nerve. 2020 03; 61(3):387-390.Posa A, Niśkiewicz I, … Kornhuber M
  • Motor unit hyperexcitability (MUH) may become manifest in needle electromyography (EMG) recordings as fasciculation potentials, myokymic discharges, or neuromyotonic discharges. Here, we describe a further MUH phenomenon.
  • Episodic Muscle Disorders. [Case Reports]
    Continuum (Minneap Minn). 2019 Dec; 25(6):1696-1711.Sansone VA
  • CONCLUSIONS: This article will help neurologists diagnose and manage episodic muscle disorders and, in particular, the periodic paralyses and the nondystrophic myotonias.
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