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(fat pad syndrome)
9,728 results
  • Organokines in disease. [Journal Article]
    Adv Clin Chem 2020; 94:261-321Chung HS, Choi KM
  • Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insul…
  • Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. [Journal Article]
    Autophagy 2020; :1-16Matsuda J, Takahashi A, … Isaka Y
  • Macroautophagy/autophagy is a lysosomal degradation system which plays a protective role against kidney injury. RUBCN/Rubicon (RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein) inhibits the fusion of autophagosomes and lysosomes. However, its physiological role in kidney proximal tubular epithelial cells (PTECs) remains uncertain. In the current study, we analyzed the …
  • Use of a bioengineered antioxidant in mouse models of metabolic syndrome. [Journal Article]
    Expert Opin Investig Drugs 2020; :1-11Griffin DM, Bitner BR, … Pautler RG
  • Background: Oxidative stress has been implicated in metabolic syndrome (MetS); however, antioxidants such as vitamin E have had limited success in the clinic. This prompts the question of what effects amore potent antioxidant might produce. A prime candidate is the recently developed bioengineered antioxidant, poly(ethylene glycol)-functionalizedhydrophilic carbon clusters (PEG-HCCs), which are …
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