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(fentaNYL transdermal )
1,281 results
  • [French trends in the misuse of Fentanyl: From 2010 to 2015]. [Journal Article]
    Therapie 2019Tournebize J, Gibaja V, … et le réseau français d’addictovigilance
  • CONCLUSIONS: Our results report significant and worrying misuse of transmucosal fentanyl formulations with wide off-label use and also primary dependence on fentanyl, regardless of galenic formulation, in patients treated for chronic non cancer pain. Given the significant risks of fentanyl, it is necessary to continue the monitoring of misuse, in particular, thanks to the activities of the French Addictovigilance network allowing a multisource approach and who provides information concerning cases of abuse, misuse and dependence.
  • Raman mapping of fentanyl transdermal delivery systems with off-label modifications. [Journal Article]
    Analyst 2019Xu T, Yilmaz H, … Wokovich AM
  • Raman mapping is a powerful and emerging tool in characterization of pharmaceuticals and provides non-destructive chemical and structural identification with minimal sample preparation. One pharmaceutical form that is suitable but has not been studied in-depth with Raman mapping is transdermal delivery systems (TDS). TDS are dosage forms designed to deliver a therapeutically effective amount of a…
  • Fentanyl assisted treatment: a possible role in the opioid overdose epidemic? [Letter]
    Subst Abuse Treat Prev Policy 2019; 14(1):50Bardwell G, Wood E, Brar R
  • CONCLUSIONS: There are known limitations to existing OAT options and there is a need to urgently evaluate alternative strategies for patients who are using illicit fentanyl not successfully treated with conventional OAT. Many patients may be attracted to, and retained in, fentanyl assisted treatment. This may be another strategy for certain patients to prevent harms caused by illicit fentanyl use, including overdose and death.
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Opioids [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The opioids are a large class of medications related in structure to the natural plant alkaloids found in opium that are derived from the resin of the opium poppy, Papaver somniferum. The natural alkaloids are also referred to as opiates and include morphine and codeine. Synthetic derivatives include heroin, fentanyl, hydromorphone, methadone, buprenorphine and others. The opioids are highly pote…
  • Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients. [Journal Article]
    Sci Rep 2019; 9(1):14635Geist MJP, Ziesenitz VC, … Mikus G
  • Transdermal fentanyl is widely used to control pain in cancer patients. The high pharmacokinetic variability of fentanyl is assumed to be due to cytochrome P450 3A-mediated (CYP3A) N-dealkylation to norfentanyl in humans. However, recently published clinical studies question the importance of the described metabolic pathway. In this small study in palliative cancer patients under real-life clinic…
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