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390 results
  • Advances in chemistry and bioactivity of parthenolide. [Review]
    Nat Prod Rep 2019Freund RRA, Gobrecht P, … Arndt HD
  • Review covering up to 07/2019 (-)-Parthenolide is a germacrane sesquiterpene lactone, available in ample amounts from the traditional medical plant feverfew (Tanacetum parthenium). Acting as a covalently reactive compound, it displays anti-inflammatory, redox-modulating, and epigenetic activities, as well as selective cytotoxicity towards cancer stem and progenitor cells. Furthermore, parthenolid…
  • Synthesis and biological profiling of parthenolide ether analogs. [Journal Article]
    Org Biomol Chem 2019; 17(45):9703-9707Freund RRA, Gobrecht P, … Arndt HD
  • Parthenolide (PTL) strongly inhibits the detyrosination of microtubules and accelerates neuronal growth. In order to access cyclic ether derivatives of PTL, ring-closing metathesis (RCM) was investigated in comparison to intramolecular sulfone alkylation. Incompatibility of RCM with epoxides was found in this setting. Biological evaluation for tubulin carboxypeptidase inhibition indicated that th…
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