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(fibric acid derivative)
108 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Fenofibrate [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Fenofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia. Fenofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis.
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antilipemic Agents [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The lipid lowering agents are used to treat hypercholesterolemia and dyslipidemias. These agents are some of the most frequently used medications in the United States. They are typically used long term and often in combination. The major effects of the lipid lowering drugs are in the lowering of serum low density lipoprotein (LDL) cholesterol levels which are believed to predispose to atheroscler…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Fibrates [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Fibrates are fibric acid derivative agents and are used to lower plasma lipids and particularly triglyceride levels. Chronic therapy with fibrates has been associated with transient mild elevations in serum aminotransferase levels and with rare instances of acute liver injury, which can be severe and evolve into chronic hepatitis, with progressive fibrosis and cirrhosis. Fibrates are derivatives …
  • Fenofibrate for Diabetic Retinopathy. [Review]
    Asia Pac J Ophthalmol (Phila) 2018 Nov-Dec; 7(6):422-426Stewart S, Lois N
  • Fenofibrate is a safe and inexpensive orally administered fibric acid derivative conventionally used to treat dyslipidemia. Two large randomized clinical trials, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) studies, demonstrated the benefit of oral fenofibrate in the treatment of patients with type 2 diabete…
  • Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review. [Case Reports]
    Medicine (Baltimore) 2018; 97(14):e0318Wang D, Wang Y
  • CONCLUSIONS: 13 cases associated with fenofibrate monotherapy-induced rhabdomyolysis were reviewed, which had been published in the English literature. The severity of fenofibrate muscle toxicity may be the result of the combination of two rhabdomyolysis enhancers, such as hypothyroidism and female gender. To avoid it, strict clinical and laboratory monitoring should be maintained, particularly hypothyroidism. Patients should be informed of possible potentially irreversible effects after taking fibrates.
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