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351 results
  • Bungarus caeruleus venom neutralization activity of Azima tetracantha Lam. Extract. [Journal Article]
    Heliyon 2019; 5(7):e02163Janardhan B, Shrikanth VM, … More SS
  • Azima tetracantha Lam. is native to Africa and India. The plant and its parts are used for treating various ailments including snake bites. The different concentrations of ethyl acetate leaf extract of A. tetracantha were used to neutralize the toxic effect of venom through dose dependent enzyme studies and in vivo studies. The extract was able to neutralize the 5' nucleotidase, phospholipase A2,…
  • New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom. [Journal Article]
    Toxins (Basel) 2018; 10(12)Amorim FG, Menaldo DL, … Sampaio SV
  • Snake venom serine proteases (SVSPs) are enzymes that are capable of interfering in various parts of the blood coagulation cascade, which makes them interesting candidates for the development of new therapeutic drugs. Herein, we isolated and characterized Moojase, a potent coagulant enzyme from Bothrops moojeni snake venom. The toxin was isolated from the crude venom using a two-step chromatograp…
  • Fungi in Mucoobstructive Airway Diseases. [Journal Article]
    Ann Am Thorac Soc 2018; 15(Suppl 3):S198-S204Li E, Landers CT, … Corry DB
  • Asthma, chronic rhinosinusitis, and related incurable allergic afflictions of the upper and lower airways are medically important because of their association with the disabling symptom of dyspnea and, at least for asthma, the potential to cause fatal asphyxiation. Extensive research over the past two decades has uncovered both the physiological basis of airway obstruction in asthma and key gover…
  • Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP). [Journal Article]
    Biochim Biophys Acta Mol Basis Dis 2018; 1864(10):3397-3406Etscheid M, Subramaniam S, … Kanse SM
  • Factor VII Activating Protease (FSAP) is a plasma protease affecting both coagulation and fibrinolysis. Although a role in hemostasis is still unclear, the identification of additional physiologic substrates will help to elucidate its role in this context. FSAP has been reported to cleave fibrinogen, but the functional consequences of this are not known. We have therefore undertaken this study to…
  • Thrombin-like enzymes from snake venom: Structural characterization and mechanism of action. [Review]
    Int J Biol Macromol 2018; 114:788-811Ullah A, Masood R, … Betzel C
  • Snake venom thrombin-like enzymes (SVTLEs) constitute the major portion (10-24%) of snake venom and these are the second most abundant enzymes present in the crude venom. During envenomation, these enzymes had shown prominently the various pathological effects, such as disturbance in hemostatic system, fibrinogenolysis, fibrinolysis, platelet aggregation, thrombosis, neurologic disorders, activat…
  • Carbon monoxide inhibits hemotoxic activity of Elapidae venoms: potential role of heme. [Journal Article]
    Biometals 2018; 31(1):51-59Nielsen VG, Frank N, Matika RW
  • Envenomation by hemotoxic enzymes continues to be a major cause of morbidity and mortality throughout the world. With regard to treatment, the gold standard to abrogate coagulopathy caused by these venoms is still the administration of antivenom; however, despite antivenom therapy, coagulopathy still occurs and recurs. Of interest, this laboratory has demonstrated in vitro and in vivo that coagul…
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