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8,027 results
  • Effect of focal adhesion kinase inhibition on osteoblastic cells grown on titanium with different topographies. [Journal Article]
    J Appl Oral Sci 2020; 28:e20190156Lopes HB, Souza ATP, … Beloti MM
  • CONCLUSIONS: Our data demonstrate the relevance of FAK in the interactions between osteoblastic cells and Ti surfaces regardless of surface topography. Nanotopography positively regulated FAK expression and integrin signaling pathway components during osteoblast differentiation. In this context, the development of Ti surfaces with the ability to upregulate FAK activity could positively impact the process of implant osseointegration.
  • Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells. [Journal Article]
    J Mol Med (Berl) 2020Montoro-García S, Alburquerque-González B, … Conesa-Zamora P
  • Tumor invasion and metastasis involve processes in which actin cytoskeleton rearrangement induced by Fascin1 plays a crucial role. Indeed, Fascin1 has been found overexpressed in tumors with worse prognosis. Migrastatin and its analogues target Fascin1 and inhibit its activity. However, there is need for novel and smaller Fascin1 inhibitors. The aim of this study was to assess the effect of compo…
  • Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration. [Journal Article]
    J Clin Invest 2020Pinto-Costa R, Castro Sousa S, … Sousa MM
  • After trauma, regeneration of adult CNS axons is abortive causing devastating neurologic deficits. Despite progress in rehabilitative care, there is no effective treatment stimulating axon growth following injury. Using models with different regenerative capacities, followed by gain- and loss-of-function analysis, we identified profilin1 (Pfn1) as a coordinator of actin and microtubules (MTs), po…
  • Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury. [Editorial]
    ACS Chem Neurosci 2020Mukherjee N, Nandi S, … Ghosh S
  • Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar formed after severe traumatic brain injury as well as spinal cord injury and play a crucial inhibitory role in axonal regeneration by selective contraction of filopodia of the growth cone of sprouting neurites. Healing of central nervous system (CNS) injury requires degradation of the glycosamine glycan backb…
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