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7,892 results
  • Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator. [Review]
    Semin Cancer Biol 2019Karamanou K, Franchi M, … Brézillon S
  • A great hallmark of breast cancer is the absence or presence of estrogen receptors ERα and ERβ, with a dominant role in cell proliferation, differentiation and cancer progression. Both receptors are related with Epithelial-to-Mesenchymal Transition (EMT) since there is a relation between ERs and extracellular matrix (ECM) macromolecules expression, and therefore, cell-cell and cell-ECM interactio…
  • Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion. [Journal Article]
    Nat Commun 2019; 10(1):3593Alieva NO, Efremov AK, … Bershadsky AD
  • Filopodia, dynamic membrane protrusions driven by polymerization of an actin filament core, can adhere to the extracellular matrix and experience both external and cell-generated pulling forces. The role of such forces in filopodia adhesion is however insufficiently understood. Here, we study filopodia induced by overexpression of myosin X, typical for cancer cells. The lifetime of such filopodia…
  • Spatiotemporal characterization of dynamic epithelial filopodia during zebrafish epiboly. [Journal Article]
    Dev Dyn 2019Rutherford NE, Wong AH, Bruce AEE
  • CONCLUSIONS: We identified protrusions on the basal surface of EVL cells as filopodia and showed that they are present throughout the EVL during epiboly. The largest number of filopodia was at the animal pole during early epiboly, which is when and where deep cell radial intercalations occur to the greatest extent. These findings suggest that EVL filopodia may function during epiboly to promote deep cell rearrangements during epiboly initiation.
  • Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors. [Journal Article]
    Dev Cell 2019Özel MN, Kulkarni A, … Hiesinger PR
  • Following axon pathfinding, growth cones transition from stochastic filopodial exploration to the formation of a limited number of synapses. How the interplay of filopodia and synapse assembly ensures robust connectivity in the brain has remained a challenging problem. Here, we developed a new 4D analysis method for filopodial dynamics and a data-driven computational model of synapse formation fo…
  • Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles. [Journal Article]
    Proc Natl Acad Sci U S A 2019; 116(33):16192-16197Freedman SL, Suarez C, … Hocky GM
  • In cells, actin-binding proteins (ABPs) sort to different regions to establish F-actin networks with diverse functions, including filopodia used for cell migration and contractile rings required for cell division. Recent experimental work uncovered a competition-based mechanism that may facilitate spatial localization of ABPs: binding of a short cross-linker protein to 2 actin filaments promotes …
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