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30 results
  • Demonstration of the broad spectrum in vitro activity of finafloxacin against pathogens of biodefence interest. [Journal Article]
    Antimicrob Agents Chemother 2019Barnes KB, Zumbrun SD, … Harding SV
  • This study investigated the in vitro activity of finafloxacin against panels of the biodefence pathogens. Broth microdilution assays were performed at neutral and acidic pH, to determine the effectiveness of the antibiotics in conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH. These results highlight the importance of evalu…
  • Fluoroquinolones structural and medicinal developments (2013-2018): Where are we now? [Review]
    Bioorg Med Chem 2019; 27(14):3005-3060Suaifan GARY, Mohammed AAM
  • Fluoroquinolones are considered one of the widely utilized antibiotics, specifically, with the recent development of newer generations such as moxifloxacin, delafloxacin and finafloxacin which possess a wider spectrum of activity and improved bioavailability. However, alarming increase in bacterial resistance reports worldwide incites medicinal chemists to employ guided-biologically-oriented-synt…
  • Developments on antibiotics for multidrug resistant bacterial Gram-negative infections. [Journal Article]
    Expert Rev Anti Infect Ther 2019; 17(6):387-401Voulgaris GL, Voulgari ML, Falagas ME
  • Introduction: The constantly increasing spread of severe infections due to multidrug-resistant (MDR) Gram-negative bacteria (GNB) is a critical threat to the global medical community. After a long period of antibiotic pipeline pause, new antibiotic compounds are commercially available or are at late stages of clinical evaluation, promising to augment the therapeutic armamentarium of clinicians ag…
  • Pharmacokinetics of Intravenous Finafloxacin in Healthy Volunteers. [Randomized Controlled Trial]
    Antimicrob Agents Chemother 2017; 61(10)Taubert M, Chiesa J, … Fuhr U
  • Finafloxacin is a novel fluoroquinolone exhibiting enhanced activity under acidic conditions and a broad-spectrum antibacterial profile. The present study assessed the pharmacokinetic properties and the safety and tolerability of finafloxacin following intravenous infusions. In this mixed-parallel-group, crossover study, healthy male and female volunteers received single ascending doses (18 volun…
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