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308,882 results
  • Indirect Tumor Inhibitory Effects of MicroRNA-124 through Targeting EZH2 in The Multiple Myeloma Cell Line. [Journal Article]
    Cell J 2020; 22(1):23-29Sabour Takanlu J, Aghaie Fard A, … Nikbakht M
  • CONCLUSIONS: It seems that assembling of H3K27me3 mark mediated by EZH2 is one of the key mechanisms of suppressing CDKN2A gene expression in MM disease. However, this suppressive function is applied by a multi-factor mechanism. In other words, targeting EZH2, as the core functional subunit of PRC2 complex, can increase expression of the downstream suppressive genes. Consequently, by increasing expression of tumor suppressor genes, myeloma cells are stopped from aberrant expansions and they become susceptible to regulated cellular death.
  • The inability of podocytes to proliferate: cause, consequences and origin. [Journal Article]
    Anat Rec (Hoboken) 2019Kriz W
  • This study presents a theoretical analysis of the problems related to the inability of podocytes to proliferate. The basis of these problems is the very high rate of glomerular filtration. Podocytes do not in general die by apoptosis or necrosis but are lost by detachment from the glomerular basement membrane (GBM) as viable cells. Podocytes situated on the outside of the filtration barrier and a…
  • Sphk1 promotes ulcerative colitis via activating JAK2/STAT3 signaling pathway. [Journal Article]
    Hum Cell 2019Liu J, Jiang B
  • Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the colon and rectum. The cause of ulcerative colitis is still unclear, although there may be a hereditary factor. SphK1 has been reported to exhibit an inhibitory effect on the occurrence and development of inflammation; however, the association between SphK1 and the progression of UC remains unclear. The aim of the presen…
  • Effects of Porcine STC-1 on Cell Metabolism and Mitochondrial Function. [Journal Article]
    Gen Comp Endocrinol 2019; :113298Yang K, Yang Y, … Ju H
  • Stanniocalcin (STC-1), a kind of glycoprotein hormone, was first found in fish and mainly regulates calcium/phosphorus metabolism in the body. To explore the biological function of the porcine STC-1 gene, the effects of changes in stanniocalcin expression on cellular metabolism and mitochondrial function were studied. A vector overexpressing the STC-1 gene and an siRNA silencer of the STC-1 gene …
  • The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of Galantamine. [Journal Article]
    Biochem Pharmacol 2019; :113665Gowayed MA, Rothe K, … Refaat R
  • CONCLUSIONS: Selective α7nAChR blockade interrupted the anti-inflammatory effect of galantamine in the spleen and joints of arthritic rats. In healthy donors, galantamine could strengthen the suppressive activity of Tregs; while in RA patients it did not modulate the function of Tregs significantly. Further studies are necessary to investigate whether modulation of the cholinergic nervous system, especially α7nAChR, could have impact on the disturbed immune system in RA, which may open up a new treatment option of autoimmune diseases.
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