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505,732 results
  • How we manage Bing-Neel syndrome. [Review]
    Br J Haematol 2019Castillo JJ, Treon SP
  • Bing-Neel syndrome (BNS) is an uncommon presentation of Waldenström macroglobulinaemia (WM), seen during the course of the disease in about 1% of patients. BNS occurs when WM cells gain access to the central nervous system (CNS) causing neurological deficits. The diagnosis of BNS is suggested by the presence of radiological abnormalities, such as leptomeningeal enhancement on magnetic resonance i…
  • Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury. [Journal Article]
    Osteoarthritis Cartilage 2019Brophy RH, Cai L, … Rai MF
  • CONCLUSIONS: Elevated POSTN may provide a synovial fluid biomarker of subacute ACL injury setting separate from OA. Increased expression of POSTN in ACL suggests that the injured ACL may play a pivotal role in POSTN production, which is sensitive to time-from-injury. Previous studies have shown potential catabolic effects of POSTN, raising the possibility that POSTN contributes to the initiation of joint degeneration and may offer a window-of-opportunity to intervene in the early stages of post-traumatic OA.
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