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57,618 results
  • A case of severe hepatotoxicity induced by cisplatin and 5-fluorouracil. [Case Reports]
    Int Cancer Conf J 2020; 9(1):24-27Yaegashi A, Yoshida K, … Toyama A
  • Severe hepatotoxicity from combination chemotherapy with cisplatin and 5-fluorouracil is a rare adverse effect. In this case report, we present a case with severe hepatotoxicity immediately following chemotherapy with cisplatin and 5-fluorouracil. This female patient had previously been treated with this combination with no hepatotoxicity. The elevated liver enzymes quickly normalized after chemo…
  • Making sense of adjuvant chemotherapy in colorectal cancer. [Review]
    J Gastrointest Oncol 2019; 10(6):1183-1192Chan GHJ, Chee CE
  • Surgical resection is the only curative treatment for locoregional colon cancer. The goal of adjuvant chemotherapy is to eradicate micro-metastatic disease and improve survival. This has been most clearly demonstrated in stage III (node-positive) disease, whereas benefit of adjuvant chemotherapy in stage II disease remains controversial. In stage III colon cancer, 6 months of adjuvant chemotherap…
  • Interleukin-8 associated with chemosensitivity and poor chemotherapeutic response to gastric cancer. [Journal Article]
    J Gastrointest Oncol 2019; 10(6):1120-1132Limpakan Yamada S, Wongsirisin P, … Limtrakul Dejkriengkraikul P
  • CONCLUSIONS: Upregulation of IL-8 after drug intervention might be useful as predictive biomarker in monitoring drug resistance in GC patients; however, this needs to be confirmed among a larger number of patients and with control groups that are properly age-paired. The established primary gastric culture could serve as a valuable tool for chemotherapy screening, while the repeated usage of platinum drugs may result in drug resistance via upregulation of IL-8 levels.
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