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57,117 results
  • Contemporary management of actinic keratosis. [Journal Article]
    J Dermatolog Treat 2019; :1-12Navarrete-Dechent C, Marghoob AA, Marchetti MA
  • Actinic keratosis (AK) is a skin lesion characterized by intraepithelial keratinocyte dysplasia and molecular alterations shared with normal chronically sun-damaged skin and squamous cell carcinoma (SCC). AK can undergo spontaneous regression, stable existence, or malignant transformation to cutaneous SCC with progression rates to SCC ranging from 0% to 0.5% per lesion-year and AK spontaneous reg…
  • CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure. [Journal Article]
    Sci Rep 2019; 9(1):14861Tsunekuni K, Konno M, … Ishii H
  • Cancer stem cells (CSCs) are involved in metastatic colorectal cancer recurrence, but no effective therapy targeting these cells is currently available. Because trifluridine (FTD)/tipiracil therapy is used for refractory colorectal cancer, we sought to determine whether FTD is effective against CSC-like cells. CD44+CD133+ high-expressing and other populations of human DLD-1 colon cancer cells wer…
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