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2,609 results
  • Silk Fibroin as a Novel Alcohol-Resistant Excipient for Sustained-Release Tablet Formulation. [Journal Article]
    AAPS PharmSciTech 2019; 20(7):279Kozak J, Rabiskova M, Lamprecht A
  • Concomitant intake of alcoholic beverages with sustained-release oral formulations may potentially lead to dose dumping. Alcohol-resistance testing is currently a requirement for the manufacturers by regulatory authorities. Silk fibroin produced by silkworm Bombyx mori is suggested in this work as a potential alternative to a narrow spectrum of alcohol-resistant excipients. Oxycodone HCl, tramado…
  • Profiling the interaction of 1-phenylbenzimidazoles to cyclooxygenases. [Journal Article]
    J Mol Recognit 2019; :e2801Gómez-Castro CZ, López-Martínez M, … Padilla-Martínez II
  • In the design of 1-phenylbenzimidazoles as model cyclooxygenase (COX) inhibitors, docking to a series of crystallographic COX structures was performed to evaluate their potential for high-affinity binding and to reproduce the interaction profile of well-known COX inhibitors. The effect of ligand-specific induced fit on the calculations was also studied. To quantitatively compare the pattern of in…
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