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Unbound Medicine.
(flurbiprofen†)
2,674 results
  • Optimizing Ophthalmic Delivery of a Poorly Water Soluble Drug from an Aqueous In situ gelling system. [Journal Article]
    Eur J Pharm Biopharm. 2020 Jun 26 [Online ahead of print]Senjoti FG, Timmins P, … Smith AM
  • Poorly soluble drugs are often unsuitable to incorporate in ocular in situ gelling systems due to the aqueous based gelling formulations and low volumes administered. For such formulations to be successful, the administered drug must have sufficient solubility to diffuse from the formulation to the eye and should not affect the gelation of the in situ gelling material. Drug salt forms can improve…
  • ESR INVESTIGATIONS of X-RAY EXPOSED DRUGS. [Journal Article]
    J Pharm Biomed Anal. 2020 May 22; 188:113311.Sarcan ET, Tas A, … Hekimoglu B
  • X-ray is used in several areas for analysis, imaging, sterilisation and security. X-ray machines are increasingly used in the entrance of the airports, shopping centres, etc. for security purposes. Therefore, human beings and belongings are frequently exposed to X-ray by transiting these checkpoints at various sites such as airports, shopping centres etc. This study aims is to investigate the X-r…
  • Flurbiprofen as a biphenyl scaffold for the design of small molecules binding to PD-L1 protein dimer. [Review]
    Biochem Pharmacol. 2020 May 21; 178:114042.Bailly C, Vergoten G
  • Small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched to offer anticancer oral treatment modalities. Different small molecules have been designed, such as BMS-202 and BMS-1166 which potently bind to PD-L1, sequestering the protein dimer and thus preventing cancer cells to escape antitumor immune responses. A (top → down) deconvolution of BMS compounds has characterized …
  • Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People. [Journal Article]
    J Pharmacol Exp Ther. 2020 May 18 [Online ahead of print]McDonald MG, Henderson LM, … Rettie AE
  • CYP2C9 is a major form of human liver cytochrome P450 that is responsible for the oxidative metabolism of several widely used low therapeutic index drugs, including (S)-warfarin and phenytoin. In a cohort of Alaskan Native people, ultra-rare or novel CYP2C9 protein variants, M1L (rs114071557), N218I (rs780801862) and P279T (rs182132442, CYP2C9*29), are expressed with higher frequencies than the w…
  • Fast off-line FPSE-HPLC-PDA determination of six NSAIDs in saliva samples. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci. 2020 May 01; 1144:122082.Tartaglia A, Kabir A, … Locatelli M
  • A fast off-line FPSE-HPLC-PDA method has been reported that allows simultaneous clean up and determination of six non-steroidal anti-inflammatory drugs (NSAIDs) in saliva samples from healthy volunteers. Particularly, furprofen, indoprofen, ketoprofen, fenbufen, flurbiprofen, and ibuprofen were chromatographically resolved. Benzyl paraben was chosen as the internal standard (BzPB, IS). These targ…
  • Determination of the Permeation and Penetration of Flurbiprofen into Cadaveric Human Pharynx Tissue. [Journal Article]
    Clin Pharmacol. 2020; 12:13-20.Turner R, Wevrett SR, … Shea T
  • CONCLUSIONS: Flurbiprofen from spray and lozenge formulations penetrated human cadaveric pharynx tissue, indicating that flurbiprofen can reach all layers of the pharynx mucosal tissue, including the underlying lamina propria, which contains blood vessels and nerve fibers that contribute to pain during sore throat. This suggests that flurbiprofen may have a local mechanism of action for sore throat, although this has yet to be determined.
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