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(foot and mouth disease)
10,367 results
  • Monoclonal Antibody Targeting a Conserved N-Terminal Epitope on 2Apro of Enteroviruses. [Journal Article]
    Monoclon Antib Immunodiagn Immunother 2019; 38(5):220-223Yi K, Xie L, Li Y
  • Several members of enteroviruses (EVs) that belong to the EVs A and B species cause hand, foot, and mouth disease (HFMD) in infants and young children. The virus-specific protease 2Apro is conserved in all the EV species, thus developing a monoclonal antibody (mAb) against 2Apro may facilitate the identification from the HFMD-associated pathogens. In this study, we achieved a murine mAb, named 5A…
  • Early IgG Response to Foot and Mouth Disease Vaccine Formulated with a Vegetable Oil Adjuvant. [Journal Article]
    Vaccines (Basel) 2019; 7(4)Cui X, Wang Y, … Hu S
  • The present study evaluated soybean oil (SO) containing vitamin E (VE) and ginseng saponins (GS) (SO-VE-GS) for their adjuvant effect on foot-and-mouth disease (FMD) vaccine. Since mineral oil ISA 206 is a common adjuvant used in the FMD vaccine, it was used as a control adjuvant in this study. VE and GS were found to have a synergistic adjuvant effect. When mice were immunized with the FMD vacci…
  • A neonatal murine model of coxsackievirus A4 infection for evaluation of vaccines and antiviral drugs. [Journal Article]
    Emerg Microbes Infect 2019; 8(1):1445-1455Zhang Z, Zhang X, … Shi W
  • Coxsackievirus A4 (CVA4) infection can cause hand, foot and mouth disease (HFMD), an epidemic illness affecting neonatal and paediatric cohorts, which can develop to severe neurological disease with high mortality. In this study, we established the first ICR mouse model of CVA4 infection for the evaluation of inactivated vaccines and antiviral drug screening. The CVA4 YT226R strain was selected t…
  • Environmental Persistence of Foot and Mouth Disease Virus Applied to Endemic Regions. [Review]
    Transbound Emerg Dis 2019Mielke SR, Garabed R
  • The consequences of foot-and-mouth disease impact regional economies and food security through animal mortality and morbidity, trade restrictions, and burdens to veterinary infrastructure. Despite efforts to control the disease, some regions, mostly in warmer climates, persistently report disease outbreaks. Consequently, it is necessary to understand how environmental factors influence transmissi…
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