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617,902 results
  • Galectin-3 modulates postnatal subventricular zone gliogenesis. [Journal Article]
    Glia 2019Al-Dalahmah O, Campos Soares L, … Szele FG
  • Postnatal subventricular zone (SVZ) neural stem cells generate forebrain glia, namely astrocytes and oligodendrocytes. The cues necessary for this process are unclear, despite this phase of brain development being pivotal in forebrain gliogenesis. Galectin-3 (Gal-3) is increased in multiple brain pathologies and thereby regulates astrocyte proliferation and inflammation in injury. To study the fu…
  • Organoid single-cell genomic atlas uncovers human-specific features of brain development. [Journal Article]
    Nature 2019; 574(7778):418-422Kanton S, Boyle MJ, … Camp JG
  • The human brain has undergone substantial change since humans diverged from chimpanzees and the other great apes1,2. However, the genetic and developmental programs that underlie this divergence are not fully understood. Here we have analysed stem cell-derived cerebral organoids using single-cell transcriptomics and accessible chromatin profiling to investigate gene-regulatory changes that are sp…
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