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7,086,654 results
  • The Pangenome: Diversity, Dynamics and Evolution of Genomes: Eukaryotic Pangenomes [BOOK]
    . Springer: Cham (CH) Tettelin Hervé H Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA grid.411024.2 0000 0001 2175 4264 Medini Duccio D GSK Vaccines R&D, Siena, Italy Richard Guy-Franck GF 0000-0002-8233-3532 Institut Pasteur, Department Genomes & Genetics, Paris, France grid.428999.7 0000 0001 2353 6535 CNRS, Paris, France grid.4444.0 0000 0001 2112 9282 BOOK
  • The first eukaryotes emerged from their prokaryotic ancestors more than 1.5 billion years ago and rapidly spread over the planet, first in the ocean, later on as land animals, plants, and fungi. Taking advantage of an expanding genome complexity and flexibility, they invaded almost all known ecological niches, adapting their body plan, physiology, and metabolism to new environments. This increase…
  • Growth of twisted bilayer graphene through two-stage chemical vapor deposition. [Journal Article]
    Nanotechnology. 2020 Jul 07 [Online ahead of print]Chu CM, Woon WY
  • We investigate growth of twisted bilayer graphene through a two-stage chemical vapor deposition (CVD). Exploiting the synergetic nucleation and growth dynamics involving carbon sources from the residual carbon impurities in Cu bulk and gaseous CHx, sub-millimeter-sized single crystalline graphene grains with multiple merged adlayer grains formed underneath are grown on Cu substrate. The distribut…
  • Magnetic field effect on trivial and topological bound states of superconducting quantum dot. [Journal Article]
    J Phys Condens Matter. 2020 Jul 07 [Online ahead of print]Górski G, Kucab K, Domanski T
  • We investigate the properties of a quantum dot embedded between the normal and superconducting leads which is additionally side-attached to the topological superconducting nanowire, hosting the Majorana modes. This setup enables formation of the trivial (finite-energy) bound states induced in the quantum dot through the superconducting proximity effect, coexisting/competing with the topological (…
  • Bone interface modulates drug resistance in breast cancer bone metastasis. [Journal Article]
    Colloids Surf B Biointerfaces. 2020 Jun 26; 195:111224.Kar S, Katti DR, Katti KS
  • Metastatic breast cancer cells on arriving at bone site interact with the bone cells to influence their growth, proliferation, and chemoresistance. There are currently no effective therapeutics available in the clinic for bone metastases. Many existing anti-cancer therapeutics are ineffective at the metastatic bone site due to a lack of accurate models of breast cancer bone metastasis for drug sc…
  • Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse. [Journal Article]
    Ecotoxicol Environ Saf. 2020 Jul 04; 202:110902.Leitch AC, Abdelghany TM, … Wright MC
  • The ionic liquid 1-octyl-3-methylimidazolium (M8OI) has been found in the environment and identified as a hazard for triggering the liver disease primary biliary cholangitis (PBC). Given limited toxicity data for M8OI and other structurally-related ionic liquids, target organs for M8OI toxicity were examined. Adult male C57Bl6 mice were acutely exposed to 0-10 mg/kg body weight M8OI via 2 intrape…
  • Symbiosis of sulfate-reducing bacteria and methanogenic archaea in sewer systems. [Journal Article]
    Environ Int. 2020 Jul 04; 143:105923.Shi X, Gao G, … Jin P
  • Sulfide and methane emissions always simultaneously exist in natural environment and constitute a major topic of societal concern. However, the metabolic environments between sulfate-reducing bacteria (SRB) and methanogenic archaea (MA) exist a great difference, which seems to be opposite to the coexisting phenomenon. To explore this issue, the comprehensive biofilm structures, substrate consumin…
  • MeCP2 inactivation of LncRNA GAS5 triggers cardiac fibroblasts activation in cardiac fibrosis. [Journal Article]
    Cell Signal. 2020 Jul 04 [Online ahead of print]Tao H, Shi P, … Ding XS
  • Long non coding RNA growth arrest-specific transcript 5 (LncRNA GAS5) participate in the formation of fibrosis diseases. However, the key role of LncRNA GAS5 in the development of cardiac fibrosis remains unclear. Accumulating evidence suggests that DNA methylation alterations play a central role in cardiac fibroblast activation. In this study, we explored MeCP2 inactivation of LncRNA GAS5 leads …
  • Pharmacokinetic Investigation of Synthetic Cannabidiol Oral Formulations in Healthy Volunteers. [Journal Article]
    Eur J Pharm Biopharm. 2020 Jul 04 [Online ahead of print]Izgelov D, Davidson E, … Hoffman A
  • Recent advances in the research of medicinal cannabis has placed the non-intoxicating cannabinoid cannabidiol (CBD) at the front of many investigations. The reasons behind this popularity is the compound's therapeutic properties, alongside a safe profile of administration lacking addictive properties such as euphoric state of mind and characterized with a wide dosing range. Oral administration of…
  • Nanoscale infrared probing of amyloid formation within the pleomorphic adenoma tissue. [Journal Article]
    Biochim Biophys Acta Gen Subj. 2020 Jul 04 [Online ahead of print]Paluszkiewicz C, Piergies N, … Kwiatek WM
  • CONCLUSIONS: The application of AFM-IR allows to determine changes in the protein secondary structures between the fibrils and the regions outside them. It has been proved that, for the former areas, the α-helix/random coil/ β-sheet components dominate, while for the latter regions the α-helix/random coil indicate the main contribution to the protein composition.The FT-IR results remain in good agreement with the AFM-IR data recorded for the areas outside the fibrils of the TM. This observation confirms that by means of the conventional FT-IR method the identification of the considered fibrils structure would be impossible. Only application of the AFM-IR nanospectroscopy allow for characterization and visualization of the fibrillization process occurring within the investigated tumour tissue.
  • Neurocan contributes to perineuronal net development. [Journal Article]
    Neuroscience. 2020 Jul 04 [Online ahead of print]Schmidt S, Arendt T, … Sonntag M
  • Perineuronal nets (PNs) are matrix molecule assemblies surrounding neuronal somata, dendrites and axon initial segments in a lattice-like appearance. PN molecules are involved in many structural and physiological processes during development and in adulthood, suggesting a crucial role in normal brain function. Neurocan, as one of the main PN proteoglycans, is suggested to control important develo…
  • Ovarian mitochondrial and oxidative stress proteins are altered by glyphosate exposure in mice. [Journal Article]
    Toxicol Appl Pharmacol. 2020 Jul 04 [Online ahead of print]Ganesan S, Keating AF
  • Glyphosate (GLY) usage for weed control is extensive. To investigate ovarian impacts of chronic GLY exposure, female C57BL6 mice were orally administered saline as vehicle control (CT) or GLY at 0.25 (G0.25), 0.5 (G0.5), 1.0 (G1.0), 1.5 (G1.5), or 2 (G2.0) mg/kg for five days per wk. for 20 wks. Feed intake increased (P < .05) in G1.5 and G2.0 mice and body weight increased (P < .05) in G1.0 mice…
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