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388 results
  • Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. [Journal Article]
    N Engl J Med 2019; 381(22):2103-2113Kapur J, Elm J, … NETT and PECARN Investigators
  • CONCLUSIONS: In the context of benzodiazepine-refractory convulsive status epilepticus, the anticonvulsant drugs levetiracetam, fosphenytoin, and valproate each led to seizure cessation and improved alertness by 60 minutes in approximately half the patients, and the three drugs were associated with similar incidences of adverse events. (Funded by the National Institute of Neurological Disorders and Stroke; ESETT number, NCT01960075.).
  • Medical management of status epilepticus: Emergency room to intensive care unit. [Journal Article]
    Seizure 2019Crawshaw AA, Cock HR
  • In convulsive status epilepticus (SE), achieving seizure control within the first 1-2 hours after onset is a significant determinant of outcome. Treatment is also more likely to work and be cost effective the earlier it is given. Initial first aid measures should be accompanied by establishing intravenous access if possible and administering thiamine and glucose if required. Calling for help will…
  • Lessons from the Established Status Epilepticus Treatment Trial. [Journal Article]
    Epilepsy Behav 2019; :106296Cock HR, Coles LD, … Kapur J
  • Convulsive status epilepticus (SE) is a relatively common emergency condition affecting individuals of all ages. The primary goal of treatment is prompt termination of seizures. Where first-line treatment with benzodiazepine has failed to achieve this, a condition known as established SE (ESE), there is uncertainty about which agent to use next. The Established Status Epilepticus Treatment Trial …
  • Early polytherapy for benzodiazepine-refractory status epilepticus. [Journal Article]
    Epilepsy Behav 2019; :106367Niquet J, Lumley L, … Wasterlain CG
  • The transition from single seizures to status epilepticus (SE) is associated with malaptive trafficking of synaptic gamma-aminobutyric acid (GABAA) and glutamate receptors. The receptor trafficking hypothesis proposes that these changes are key events in the development of pharmacoresistance to antiepileptic drugs (AEDs) during SE, and that blocking their expression will help control drug-refract…
  • Rational polytherapy in the treatment of cholinergic seizures. [Review]
    Neurobiol Dis 2020; 133:104537Niquet J, Lumley L, … Wasterlain CG
  • The initiation and maintenance phases of cholinergic status epilepticus (SE) are associated with maladaptive trafficking of synaptic GABAA and glutamate receptors. The resulting pharmacoresistance reflects a decrease in synaptic GABAA receptors and increase in NMDA and AMPA receptors, which tilt the balance between inhibition and excitation in favor of the latter. If these changes are important t…
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