- Cost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease. [Journal Article]
- HMHum Mutat 2019 Jun 18
- CONCLUSIONS: smMIPs-based sequence analysis of coding and selected noncoding regions of ABCA4 enabled cost-effective mutation detection in STGD1 cases in previously unsolved cases.
- Circulating inflammation markers and prostate cancer. [Journal Article]
- PProstate 2019 Jun 18
- CONCLUSIONS: In this explorative study, we identified candidate inflammation markers of possible importance for prostate cancer pathophysiology, for further evaluation in prospective studies.
- E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer. [Journal Article]
- PProstate 2019 Jun 18
- CONCLUSIONS: Our results indicate that tight junctions are compromised in BPH and loss of E-cadherin is potentially an important underlying mechanism, suggesting targeting E-cadherin loss could be a potential approach to prevent or treat BPH.
- [Paramphistomidosis - an overview on epidemiology and clinical signs]. [Journal Article]
- TPTierarztl Prax Ausg G Grosstiere Nutztiere 2019; 47(3):184-191
- Paramphistosis is a globally occurring parasitic disease in various ruminants caused by a range of rumen flukes (including Paramphistomum cervi, Calicophoron daubneyi and Paramphistomum leydeni). In …
Paramphistosis is a globally occurring parasitic disease in various ruminants caused by a range of rumen flukes (including Paramphistomum cervi, Calicophoron daubneyi and Paramphistomum leydeni). In Europe, local occurrences of rumen fluke infection in domestic and wild ruminants have been described for decades. There is now evidence that paramphistomidosis is gaining in importance, because high prevalence rates were reported in the United Kingdom, Ireland, France, Spain, Belgium and The Netherlands. Current prevalence data from Germany are lacking. In recent investigations in northern Germany, Hesse and Bavaria, C. daubneyi was detected, which is currently the most prevalent rumen fluke in Europe. The development of therumen fluke is linked to aquatic snails as intermediate hosts. C. daubneyi and the liver fluke Fasciola hepatica share in the course of their development the same intermediate snail host, Galba truncatula. The definitive ruminant host takes up infective metacercaria. In the small intestine, the young flukes excyst and attach to the duodenum. Subsequently, they migrate to the rumen, where, as adults, they begin to release eggs. The infection can lead to severe diarrhea during the intestinal phase and death at high infection intensity. Ruminal paramphistomidosis is subclinical in most cases. Currently, coproscopic detection by the sedimentation method is the available diagnostic tool. Because of similar morphology, there is a risk of confusion with the eggs of the liver fluke F. hepatica. Paramphistomidosis can be treated with oxyclozanide. There are conflicting results regarding the effectiveness of other drugs. Therefore, prophylaxis of this parasitosis is important. Because of the similar epidemiology, control recommendations are based on those for the prevention of fasciolosis. Whether paramphistomidosis is also an emerging infectious disease in Germany cannot be currently assessed.
- [Risk factors for calf mortality influence the occurrence of antibodies against the pathogens of enzootic bronchopneumonia]. [Journal Article]
- TPTierarztl Prax Ausg G Grosstiere Nutztiere 2019; 47(3):151-165
- CONCLUSIONS: The results of this study indicate that peri- and postnatal calf management procedures may affect calf mortality and the frequency of occurrence of BRSV-AB or PIV3-AB. The influences of birth monitoring and the time of first colostrum feeding as well as dust exposure should be taken into account in future studies on the frequency of EBP and be included in the veterinary cause analysis of herd EBP-related problems.
- Transient Intraocular Pressure Fluctuations: Source, Magnitude, Frequency, and Associated Mechanical Energy. [Journal Article]
- IOInvest Ophthalmol Vis Sci 2019 Jun 03; 60(7):2572-2582
- CONCLUSIONS: Transient IOP fluctuations occur frequently and comprise a large and significant portion of the total IOP loading in the eye and should, therefore, be considered in future studies of cell mechanotransduction, ocular biomechanics, and/or clinical outcomes where transient IOP fluctuations may be important. If IOP dynamics are similar in humans, clinical snapshot IOP measurements are insufficient to capture true IOP.
- Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis. [Journal Article]
- NNeuropsychopharmacology 2019 Jun 18
- Differences in efficacy between antipsychotics and placebo in schizophrenia trials have decreased over the past decades. Previous studies have tried to identify potential explanatory factors focusing…
Differences in efficacy between antipsychotics and placebo in schizophrenia trials have decreased over the past decades. Previous studies have tried to identify potential explanatory factors focusing on response to placebo; however, it is still not clear which factors, if any, specifically moderate drug-response, as they may be different from those moderating placebo-response. Therefore, in this meta-regression analysis we explore whether there is an interaction between drug-response and placebo-response in terms of effect size. We systematically searched multiple electronic databases, ClinicalTrials.gov, and the US Food and Drug Administration website for randomized, placebo-controlled trials investigating the efficacy of antipsychotics in patients with acute schizophrenia (last update: October 2016). The main outcome was the change on the Brief Psychiatric Rating Scale or the Positive and Negative Syndrome Scale score from baseline to endpoint after at least 3 weeks of treatment. Multiple patient-, design-, and drug-related potential predictors of response were analyzed by meta-regressions, as predefined in the study protocol. Overall, 167 trials with 28,102 participants were included. Publication year, the number of participants and sites, mean dose, minimum severity threshold as an inclusion criterion, chronicity, industry sponsorship, type of rating scale, diagnostic criteria, and number of medications had a different impact on drug and placebo response. By contrast, baseline severity, duration of wash-out, study duration, and study region affected drug and placebo response in a similar way without a net effect on effect sizes. No other factors had a significant effect on either drug-response or placebo-response. In conclusion, as individual moderators may have different impact on placebo-response and drug-response, it is important to consider also the specific factors influencing drug-response in order to fully understand the difference between antipsychotics and placebo. These results shed further light on the phenomenon of decreasing effect size of antipsychotics for schizophrenia over time and should help design future randomized controlled trials in the field (Prospero registration number CRD42013003342).
- Multisensory Integration Is Modulated by Auditory Sound Frequency and Visual Spatial Frequency. [Journal Article]
- MRMultisens Res 2019 Jan 01; :1-23
- Accurate integration of auditory and visual information is essential for our ability to communicate with others. Previous studies have shown that the temporal discrepancies over which audiovisual spe…
Accurate integration of auditory and visual information is essential for our ability to communicate with others. Previous studies have shown that the temporal discrepancies over which audiovisual speech stimuli will be integrated into a coherent percept are much wider than those typically observed for simple stimuli like beeps and flashes of light. However, our sensitivity to the low-level features of simple stimuli is not constant. We hypothesized that part of the enhanced integration of audiovisual speech may be due to it consisting predominantly of the sound frequencies and visual spatial frequencies that humans are most sensitive to. Here, we examined integration behaviors for pure tones across the sound frequency spectrum and visual gratings across the spatial frequency spectrum to examine how these low-level features modulate integration. The temporal window of integration was modulated by both sound frequency and visual spatial frequency, with the widest integration window occurring when both stimuli fell within their respective peak sensitivity ranges. These results suggest that part of the increased tolerance for temporal asynchrony typically observed for audiovisual speech may be due to the differential integration of low-level stimulus features that are dominant within complex audiovisual speech.
- Relationship between dietary non-enzymatic antioxidant capacity and type 2 diabetes risk in the Japan Public Health Center-based Prospective Study. [Journal Article]
- NNutrition 2019 Mar 29; 66:62-69
- CONCLUSIONS: This finding suggests that dietary NEAC may not be appreciably associated with T2D in Japanese adults.
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- Relationship of fibroblast growth factor 21 with subclinical atherosclerosis and cardiovascular events: Multi-Ethnic Study of Atherosclerosis. [Journal Article]
- AAtherosclerosis 2019 Jun 08; 287:46-53
- CONCLUSIONS: Although FGF21 has been suggested as a CVD biomarker for people with high CVD risk, our findings do not support a role of FGF21 as a CVD biomarker in those without a history of CVD.