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(functional disease)
233,366 results
  • High microbiota reactivity of adult human intestinal IgA requires somatic mutations. [Journal Article]
    J Exp Med. 2020 Nov 02; 217(11)Kabbert J, Benckert J, … Pabst O
  • The gut is home to the body's largest population of plasma cells. In healthy individuals, IgA is the dominating isotype, whereas patients with inflammatory bowel disease also produce high concentrations of IgG. In the gut lumen, secretory IgA binds pathogens and toxins but also the microbiota. However, the antigen specificity of IgA and IgG for the microbiota and underlying mechanisms of antibody…
  • Single cell sequencing revealed the underlying pathogenesis of the development of osteoarthritis. [Journal Article]
    Gene. 2020 Jul 05 [Online ahead of print]Li C, Luo J, … Wu K
  • Osteoarthritis (OA) is a chronic degenerative change with high incidence and leads to a lower quality of life and a larger socioeconomic burden. This study aimed to explore potential crucial genes and pathways associated with OA that can be used as potential biomarkers forearly treatment. Single-cell gene expression profile of 1464 chondrocytes and 192 fibroblasts in OA were downloaded from the p…
  • d-Alanine: Distribution, origin, physiological relevance, and implications in disease. [Review]
    Biochim Biophys Acta Proteins Proteom. 2020 Jul 05 [Online ahead of print]Lee CJ, Qiu TA, Sweedler JV
  • d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its l-isomer, the characterization of d-Ala is challenging because of the need for chiral resolution and the low amounts of the d-enantiomer present. With recent improvements in measurement capabilities, research on d-Ala, along with other d-amino acids, has been growing, especially as the …
  • B cell signaling pathways - new targets for precision medicine in CLL. [Journal Article]
    Scand J Immunol. 2020 Jul 08 [Online ahead of print]Skånland SS, Karlsen L, Taskén K
  • The B cell receptor (BCR) is a master regulator of B cells, controlling cellular processes such as proliferation, migration and survival. Cell signaling downstream of the BCR is aberrantly activated in the B-cell malignancy chronic lymphocytic leukemia (CLL), supporting the pathophysiology of the disease. This insight has led to development and approval of small molecule inhibitors that target co…
  • Bioprinting stem cells: building physiological tissues one cell at a time. [Journal Article]
    Am J Physiol Cell Physiol. 2020 Jul 08 [Online ahead of print]Scognamiglio C, Soloperto A, … Cidonio G
  • Bioprinting aims to direct the spatial arrangement in three dimensions of cells, biomaterials and growth factors. The biofabrication of clinically relevant constructs for the repair or modelling of either diseased or damaged tissues is rapidly advancing, resulting in the ability to 3D print biomimetic platforms which imitate a large number of tissues in the human body. Primary tissue-specific cel…
  • Endothelial cells and angiogenesis in the horse in health and disease-A review. [Journal Article]
    Anat Histol Embryol. 2020 Jul 08 [Online ahead of print]Rieger J, Kaessmeyer S, … Plendl J
  • The cardiovascular system is the first functional organ in the embryo, and its blood vessels form a widespread conductive network within the organism. Blood vessels develop de novo, by the differentiation of endothelial progenitor cells (vasculogenesis) or by angiogenesis, which is the formation of new blood vessels from existing ones. This review presents an overview of the current knowledge on …
  • Quality of Life Assessed Using Skindex-16 Scores Among Patients With Acne Receiving Isotretinoin Treatment. [Journal Article]
    JAMA Dermatol. 2020 Jul 08 [Online ahead of print]Secrest AM, Hopkins ZH, … Dermatology PRO Consortium
  • CONCLUSIONS: The findings of this case series suggest that patients receiving isotretinoin treatment achieve greater than a 50% improvement in quality of life by month 2 and can expect approximately 4-fold to 5-fold improvements from baseline with a full course of isotretinoin. This study shows the potential of routine administration of quality of life measures to assess patient care in dermatology.
  • Beyond the HLA polymorphism: A complex pattern of genetic susceptibility to pemphigus. [Journal Article]
    Genet Mol Biol. 2020; 43(3):e20190369.Petzl-Erler ML
  • Pemphigus is a group of autoimmune bullous skin diseases that result in significant morbidity. As for other multifactorial autoimmune disorders, environmental factors may trigger the disease in genetically susceptible individuals. The goals of this review are to summarize the state of knowledge about the genetic variation that may affect the susceptibility and pathogenesis of pemphigus vulgaris a…
  • Pain trajectory defines knee osteoarthritis subgroups: a prospective observational study. [Journal Article]
    Pain. 2020 Jun 24 [Online ahead of print]Radojčić MR, Arden NK, … VIDEO trial investigators
  • Knee osteoarthritis (OA) is a heterogeneous disease, and identification of its subgroups/phenotypes can improve patient treatment and drug development. We aimed to identify homogeneous OA subgroups/phenotypes using pain development over time; to understand the interplay between pain and functional limitation in time course, and to investigate subgroups' responses to available pharmacological and …
  • Hypoxia imaging in living cells, tissues and zebrafish with a nitroreductase-specific fluorescent probe. [Journal Article]
    Analyst. 2020 Jul 08 [Online ahead of print]Fan L, Zan Q, … Wong MS
  • Hypoxia in solid tumors is directly linked to the elevated levels of endogenous nitroreductase (NTR). We present a novel fluorescent probe, namely NTNO, for nitroreductase-specific detection based on the NTR-catalyzed reduction of the nitro unit to an amine functionality, and demonstrated its application for hypoxia imaging. NTNO was designed by incorporating a nitro unit as the NTR response site…
  • Functional analysis of RXLR effectors from the New Zealand kauri dieback pathogen Phytophthora agathidicida. [Journal Article]
    Mol Plant Pathol. 2020 Jul 08 [Online ahead of print]Guo Y, Dupont PY, … Bradshaw RE
  • New Zealand kauri is an ancient, iconic, gymnosperm tree species that is under threat from a lethal dieback disease caused by the oomycete Phytophthora agathidicida. To gain insight into this pathogen, we determined whether proteinaceous effectors of P. agathidicida interact with the immune system of a model angiosperm, Nicotiana, as previously shown for Phytophthora pathogens of angiosperms. Fro…
  • Disease gene discovery in male infertility: past, present and future. [Review]
    Hum Genet. 2020 Jul 07 [Online ahead of print]Xavier MJ, Salas-Huetos A, … Veltman JA
  • Identifying the genes causing male infertility is important to increase our biological understanding as well as the diagnostic yield and clinical relevance of genetic testing in this disorder. While significant progress has been made in some areas, mainly in our knowledge of the genes underlying rare qualitative sperm defects, the same cannot be said for the genetics of quantitative sperm defects…
  • Urinary neopterin, a new marker of the neuroinflammatory status in amyotrophic lateral sclerosis. [Journal Article]
    J Neurol. 2020 Jul 08 [Online ahead of print]Lunetta C, Lizio A, … Campolo J
  • CONCLUSIONS: Our finding indicates that urine neopterin is elevated in ALS, emphasizing the role of the cell-mediated inflammation in the disease. Moreover, whether confirmed in further studies, our results will underline the neopterin's potential use as non-invasive clinical biomarker of ALS, to discriminate patients possibly candidates to clinical interventions aimed to interfere the neuroinflammatory processes.
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