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16,687 results
  • A guide to establishing a hyperthermic intraperitoneal chemotherapy program in gynecologic oncology. [Review]
    Gynecol Oncol. 2020 Jul 02 [Online ahead of print]Chambers LM, Costales AB, … Debernardo R
  • Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) may be used to treat peritoneal based malignancies, such as epithelial ovarian cancer (EOC). Despite results of clinical trials supporting an increasing indication for HIPEC in EOC, concerns have existed regarding morbidity and challenges with initiating HIPEC at an institutional level. The objective of this review…
  • [Bartter-Gitelman syndromes]. [Journal Article]
    Nephrol Ther. 2020 Jul 01 [Online ahead of print]Blanchard A, Courand PY, … Vargas-Poussou R
  • Bartter-Gitelman syndromes are rare inherited autosomal recessive salt-losing tubulopathies characterized by severe and chronic hypokalemia associated with metabolic alkalosis and secondary hyperaldosteronism. Bartter syndrome results from a furosemide-like defect in sodium reabsorption in the Henle's loop leading to hypercalciuria and defect in urinary concentration capacity. The antenatal Bartt…
  • Is Inhaled Furosemide a Potential Therapeutic for COVID-19? [Review]
    Am J Med Sci. 2020 Jun 01 [Online ahead of print]Brennecke A, Villar L, … Weaver DF
  • The potentially lethal infection caused by the novel Severe Acute Respiratory Disease Coronavirus-2 (SARS-CoV-2) has evolved into a global crisis. Following the initial viral infection is the host inflammatory response that frequently results in excessive secretion of inflammatory cytokines (e.g., IL-6 and TNFα), developing into a self-targeting, toxic "cytokine storm" causing critical pulmonary …
  • [The Role of Pharmacists in Home Medical Care of Patients with Heart Failure]. [Journal Article]
    Yakugaku Zasshi. 2020; 140(7):869-875.Sakuma E, Kawauchi J, … Watanabe J
  • In recent years, home medical care has been strongly promoted. As a consequence, the conditions managed in home medical care have become increasingly diverse. Heart failure is one of the most common disorders after malignant diseases. Patients with chronic heart failure (CHF) are often forced into hospitalization because of the inability to control symptoms with oral medications, even though they…
  • Exogenous intoxication by non-prescribed use of vitamin D, a case report. [Journal Article]
    BMC Geriatr. 2020 Jun 24; 20(1) Paula ALT, Gonzaga WPF, … Markus J
  • CONCLUSIONS: Our report summarizes the possible consequences of using a vitamin compound without supervision of a competent professional, as these substances are mistakenly considered non-toxic. To add, little information is available about the supplements' metabolism and their biological effects. Therefore, It is difficult to diagnose intoxication. This case report shows that even the self-administration of a product designed to bring health benefits can become a risky behavior. These vitamin and mineral supplements are supposed to bring patient empowerment and reduce government spending in health-care, but indeed represent a significant public health concern due to possible overdose and drug interactions.
  • Furosemide use in Italian neonatal intensive care units: a national survey. [Journal Article]
    Ital J Pediatr. 2020 Jun 22; 46(1):86.Manfredini VA, Cerini C, … on the behalf of study Group of Neonatal Pharmacoterapy of the Italian Society of Neonatology
  • CONCLUSIONS: In Italian NICUs, furosemide is commonly prescribed to term and preterm newborns for label and unlabeled indications. Doses greater-than-recommended are frequently administered. Such use is not necessarily inappropriate. More research is required to assess the efficacy and safety of unlabeled use.
  • The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes. [Journal Article]
    J Enzyme Inhib Med Chem. 2020 Dec; 35(1):1359-1362.Argan O, Çıkrıkçı K, … Gencer N
  • Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention. In this study, we aimed to determine the in vitro effects of 35 frequently used cardiac drugs on human carbonic anhydrase I (hCA I) and II (hCA II). The inhibitory effects of the drugs on hCA I and hCA II were de…
  • Case Report on Paediatric Nephrotic Syndrome. [Case Reports]
    EJIFCC. 2020 Jun; 31(2):164-168.Prince S, Naresh K, Tulasi R
  • Nephrotic syndrome (NS) is a glomerular disorder typically characterized by gross proteinuria, hypoalbuminemia, hyperlipidemia, and peripheral oedema. We report the case of a 2-year-old male toddler weighing 15 kg with a 1-week history of swelling around the eyes and both legs, and generalized body swelling. She had a history of fever, cough and decreased urine output. Examination revealed bilate…
  • Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion. [Journal Article]
    Toxins (Basel). 2020 Jun 12; 12(6)Mihaila SM, Faria J, … Masereeuw R
  • In chronic kidney disease (CKD), the secretion of uremic toxins is compromised leading to their accumulation in blood, which contributes to uremic complications, in particular cardiovascular disease. Organic anion transporters (OATs) are involved in the tubular secretion of protein-bound uremic toxins (PBUTs). However, OATs also handle a wide range of drugs, including those used for treatment of …
  • Case 279: Central-Variant Posterior Reversible Encephalopathy Syndrome. [Journal Article]
    Radiology. 2020 Jul; 296(1):239-243.Abraham P, Longardner K, … Handwerker J
  • HistoryA 25-year-old woman with recently diagnosed systemic lupus erythematosus and class IV lupus nephritis confirmed with biopsy and treated with mycophenolate mofetil presented with a 2-day history of progressively worsening edema of her face and lower extremities. She had no antecedent infection or vaccination. She was admitted to the hospital and treated with methylprednisolone, furosemide, …
  • 18F-FDG PET/CT images defined the true extent of a urothelial bladder carcinoma. [Case Reports]
    Urol Case Rep. 2020 Nov; 33:101289.Almeida LS, Santos AO, … Etchebehere E
  • A patient was referred, after neoadjuvant chemotherapy, for pre-surgical evaluation of urothelial bladder carcinoma (single lesion). Two thickenings in the left ureter wall identified on the CT scan were equivocal for malignancy. 18F-FDG PET/CT with delayed pelvic images, hyperhydration, and furosemide showed hypermetabolic ureteral metastases and multifocal bladder tumors. There were no lymph no…
  • Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules. [Journal Article]
    Molecules. 2020 Jun 09; 25(11)Garousi J, Vorobyeva A, Altai M
  • Affibody molecules are the most studied class of engineered scaffold proteins (ESPs) in radionuclide molecular imaging. Attempts to use affibody molecules directly labelled with radiometals for targeted radionuclide therapy were hampered by the high uptake and retention of radioactivity in kidneys. Several promising strategies have been implemented to circumvent this problem. Here, we investigate…
  • The potential risk factors of nephrotoxicity during vancomycin therapy in Chinese adult patients. [Journal Article]
    Eur J Hosp Pharm. 2020 Jun 10 [Online ahead of print]Wang Y, Yang J, … Deng Y
  • CONCLUSIONS: Fluconazole and voriconazole might be potential risk factors for vancomycin nephrotoxicity, besides furosemide and torasemide. It is not recommended to use imipenem cilastatin sodium and vancomycin at the same time. If necessary, meropenem may be safer. Appropriate combination drugs, cautious initial dose or timely dose adjustment might reduce the occurrence of nephrotoxicity when using vancomycin.
  • Very High Dose Furosemide Continuous Infusions: A Case Series. [Journal Article]
    J Card Fail. 2020 Jun 05 [Online ahead of print]Wilczynski JA, DeCaro MV, … Danelich IM
  • CONCLUSIONS: Very high dose furosemide continuous infusions provide a significant increase in diuresis without worsening renal function, disturbing electrolytes, or increasing the risk of ototoxicity. Further studies are necessary to examine the efficacy and safety of this novel strategy.
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