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131 results
  • Landscape of RAS Variations in 17,993 Pan-cancer Patients Identified by Next-generation Sequencing. [Letter]
    Pathol Oncol Res. 2020 Jun 30 [Online ahead of print]Zhou S, Zhang D, … Wu H
  • RAS family genes (HRAS, KRAS and NRAS) were frequently observed in several tumors. The expression of constitutively active RAS proteins mediated by RAS variations promote the development of tumors. KRAS is an important prognostic and drug resistance biomarker. It would also be a promising drug target. Several trials which evaluating the efficacy of RAS G12C inhibitor in solid tumors are initiated…
  • Development and verification of a personalized immune prognostic feature in breast cancer. [Journal Article]
    Exp Biol Med (Maywood). 2020 Jun 29 [Online ahead of print]Wang H, Wu L, Wang H
  • Breast cancer is among the highest prevalent malignant tumors worldwide with a low survival ratio. Immune-related genes have great potential as prognostic indicator in many types of tumors. Therefore, we have attempted to develop immune-related gene markers to enhance the prognosis of breast cancer. 17-IRGPs signature was constructed as a newly developed prognostic indicator to predict the surviv…
  • A review on methods for diagnosis of breast cancer cells and tissues. [Review]
    Cell Prolif. 2020 Jun 12 [Online ahead of print]He Z, Chen Z, … Li W
  • Breast cancer has seriously been threatening physical and mental health of women in the world, and its morbidity and mortality also show clearly upward trend in China over time. Through inquiry, we find that survival rate of patients with early-stage breast cancer is significantly higher than those with middle- and late-stage breast cancer, hence, it is essential to conduct research to quickly di…
  • Long noncoding RNA lnc-LOC645166 promotes adriamycin resistance via NF-κB/GATA3 axis in breast cancer. [Journal Article]
    Aging (Albany NY). 2020 May 27; 12(10):8893-8912.Zheng R, Jia J, … Huang O
  • Chemoresistance remains a significant obstacle for effective adriamycin (ADR) treatment in breast cancer. Recent efforts have revealed that long noncoding RNAs (lncRNAs) play a crucial role in cancer biology, including chemoresistance. We identified the lncRNA LOC645166 was upregulated in adriamycin resistant-breast cancer cells by Microarray analysis, which was further confirmed in the tissues o…
  • circ_103809 promotes breast cancer progression by regulating the PI3K/AKT signaling pathway. [Journal Article]
    Oncol Lett. 2020 Jun; 19(6):3725-3730.Qiu X, Wang Q, … Xue J
  • Breast cancer is one of the most common cancer types in the world. This study was carried out to investigate the functional role of circular RNA circ_103809 in breast cancer. The expression of hsa_circ_103809 in breast cancer tissues and breast cancer cells were verified. After transfection, the expression of hsa_circ_103809 in the cells was detected by quantitative real-time polymerase chain rea…
  • Clinical Effects of Neoadjuvant Chemotherapy in Treating Breast Cancer. [Journal Article]
    Cancer Biother Radiopharm. 2020 Apr 24 [Online ahead of print]Sun C, Shi L, … Zhang X
  • CONCLUSIONS: NAC is effective among the majority of patients with breast cancer. In addition, tumor size determined through clinical palpation is generally in accordance with responses to chemotherapy, and consistent performance is observed for three systems in grading responses to chemotherapy.
  • SAG expression associates with COPB2-related signaling and a poorer prognosis in breast cancer. [Journal Article]
    Aging (Albany NY). 2020 01 11; 12(1):902-911.Liu A, Zhang S, … Zhu S
  • SAG is an essential RING component of the Cullin-RING ligase (CRL) E3 ubiquitin ligase complex, which regulates diverse signaling pathways and biological processes, including cell apoptosis, embryonic development, angiogenesis, and tumorigenesis. In the present study, we revealed that SAG gene expression is upregulated in breast cancer cells and that SAG overexpression is associated with signific…
  • Schwannoma of the long thoracic nerve in the left axilla: a case report. [Journal Article]
    J Int Med Res. 2019 Dec 04 [Online ahead of print]Tian J, Huang Q, Chen Z
  • Schwannoma, which is also known as neurilemmoma, is a type of tumor that arises from the peripheral nerve sheaths. Cases of schwannomas located in different regions have been reported. Some schwannomas present as asymptomatic masses, while others cause discomfort, such as pain and numbness. Magnetic resonance imaging (MRI) is a valuable diagnostic tool. A 23-year-old woman presented to our hospit…
  • Luteolin exhibits anti-breast cancer property through up-regulating miR-203. [Journal Article]
    Artif Cells Nanomed Biotechnol. 2019 Dec; 47(1):3265-3271.Gao G, Ge R, … Liu S
  • Luteolin is a representative of natural flavonoid that has anti-tumour properties. This study designed to check its impact on breast cancer and the underlying mechanisms. MDA-MB-453 and MCF-7 cells were administrated with luteolin and the following techniques were carried out: CCK-8 assay, FITC-PI double-staining and Western blot. qRT-PCR analysis was utilized to see the effects of luteolin on mi…
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