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2,148 results
  • The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of Galantamine. [Journal Article]
    Biochem Pharmacol 2019; :113665Gowayed MA, Rothe K, … Refaat R
  • CONCLUSIONS: Selective α7nAChR blockade interrupted the anti-inflammatory effect of galantamine in the spleen and joints of arthritic rats. In healthy donors, galantamine could strengthen the suppressive activity of Tregs; while in RA patients it did not modulate the function of Tregs significantly. Further studies are necessary to investigate whether modulation of the cholinergic nervous system, especially α7nAChR, could have impact on the disturbed immune system in RA, which may open up a new treatment option of autoimmune diseases.
  • Therapeutic approaches to cholinergic deficiency in Lewy body diseases. [Journal Article]
    Expert Rev Neurother 2019; :1-13Barrett MJ, Cloud LJ, … Holloway KL
  • Introduction: Cortical cholinergic denervation resulting from degeneration of the nucleus basalis of Meynert (NBM) is a primary contributor to cognitive impairment and neuropsychiatric symptoms in the Lewy body diseases Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB). Considering the morbidity associated with cognitive impairment and neuropsychiat…
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