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177,005 results
  • Rare variants in FANCA induce premature ovarian insufficiency. [Journal Article]
    Hum Genet 2019Yang X, Zhang X, … Wu Y
  • Premature ovarian insufficiency (POI) is a major cause of reduced female fertility and affects approximately 1% women under 40 years of age. Recent advances emphasize the genetic heterogeneity of POI. Fanconi anemia (FA) genes, traditionally known for their essential roles in DNA repair and cytogenetic instability, have been demonstrated to be involved in meiosis and germ cell development. Here, …
  • WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis. [Journal Article]
    Development 2019Qin Y, Zhou Y, … Gao F
  • WDR62 is the second most common genetic alteration associated with microcephaly. Our previous study demonstrates that Wdr62 is required for germ cell meiosis initiation and the majority of male germ cells are lost as the meiotic defect of first wave spermatogenesis. Strikingly, in this study, we found that the initiation of meiosis of following spermatogenesis was not affected and the germ cells …
  • Microscopic Assessment of Dead Cell Ratio in Cryopreserved Chicken Primordial Germ Cells. [Journal Article]
    Microsc Microanal 2019; :1-6Svoradová A, Makarevich A, … Chrenek P
  • This study aimed to compare three methods of cell death assessment [trypan blue exclusion (TBE), propidium iodide viability assay (PIVA), and transmission electron microscopy] to evaluate fresh and frozen-thawed chicken primordial germ cells (PGCs). For this study, chicken PGCs were collected from ROSS 908 and Oravka breed hens, cryopreserved-thawed according to the protocol, and submitted for di…
  • An assessment of the immune costs associated with meiotic drive elements in Drosophila. [Journal Article]
    Proc Biol Sci 2019; 286(1911):20191534Lea JK, Unckless RL
  • Most organisms are constantly adapting to pathogens and parasites that exploit their host for their own benefit. Less studied, but perhaps more ubiquitous, are intragenomic parasites or selfish genetic elements. These include transposable elements, selfish B chromosomes and meiotic drivers that promote their own replication without regard to fitness effects on hosts. Therefore, intragenomic paras…
  • Male age and its association with reproductive traits in captive and wild house sparrows. [Journal Article]
    J Evol Biol 2019Girndt A, Cockburn G, … Schroeder J
  • Evolutionary theory predicts that females seek extra-pair fertilisations from high-quality males. In socially monogamous bird species, it is often old males that are most successful in extra-pair fertilisations. Adaptive models of female extra-pair mate choice suggest that old males may produce offspring of higher genetic quality than young males because they have proven their survivability. Howe…
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