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1,419 results
  • Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas. [Review]
    Cochrane Database Syst Rev 2020; 1:CD009229Dhawan S, Patil CG, … Venteicher AS
  • CONCLUSIONS: Given the high risk of bias in the included study, the results of this analysis must be interpreted with caution. Early radiation therapy was associated with the following adverse effects: skin reactions, otitis media, mild headache, nausea, and vomiting. People with LGG who underwent early radiotherapy showed an increase in time to progression compared with people who were observed and had radiotherapy at the time of progression. There was no significant difference in overall survival between people who had early versus delayed radiotherapy; however, this finding may be due to the effectiveness of rescue therapy with radiation in the control arm. People who underwent early radiation had better seizure control at one year than people who underwent delayed radiation. There were no cases of radiation-induced malignant transformation of LGG. However, it remained unclear whether there were differences in memory, executive function, cognitive function, or quality of life between the two groups since these measures were not evaluated.
  • Multifocal Intracranial Ganglioglioma in a Sexagenarian: A Case Report and Review of the Current Literature. [Journal Article]
    World Neurosurg 2019Mansour S, Luther E, … Komotar R
  • CONCLUSIONS: Multifocal intracranial gangliogliomas are exceedingly rare tumors, especially in adults. These tumors present unique management barriers, as they are multifocal at the time of diagnosis, making resection more technically challenging. In our review, the average age at diagnosis was 19.2, and 80% of the cases had at least one lesion in the temporal lobe. Two studies opted for resection of intracranial tumors, whereas the remaining studies performed biopsy with conservative management and serial imaging. Biopsy was performed in all cases. We present the first case of an intracranial multifocal ganglioglioma in a patient over 40 with lesions in the occipital lobe, corpus callosum and frontal lobe at presentation.
  • Cells with ganglionic differentiation frequently stain for VE1 antibody: a potential pitfall. [Journal Article]
    Brain Tumor Pathol 2019Tan CL, Lian DWQ, … Chang KTE
  • Mitogen-activated protein kinase (MAPK) pathway plays a major role in pediatric low-grade gliomas (pLGGs). Immunohistochemistry with mutant-specific antibody, VE1, has appeared to be the most affordable and rapidly deployable method to identify tumors with aberrant MAPK signaling pathway, by highlighting tumor with BRAFV600E mutation. Nonetheless, positive staining cases but not associated with B…
  • Clinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors. [Journal Article]
    J Neuropathol Exp Neurol 2020; 79(1):67-73Ho CY, Bornhorst M, … Rodriguez FJ
  • Neuronal/mixed glioneuronal tumors are central nervous system neoplasms composed of neoplastic neuronal cell components or a mixture of glial and neuronal elements. They occur in cerebral hemispheres, posterior fossa, and spinal cord. Compared with other tumors at these locations, diencephalic neuronal/glioneuronal tumors are very rare and therefore not well characterized. We hereby performed cli…
  • Ganglioglioma of the Right Cerebrothalamus in a 7-Year-Old Quarter Horse Cross Gelding. [Case Reports]
    Front Vet Sci 2019; 6:356Easton-Jones C, Woolard K, … Aleman M
  • Intracranial neoplasia in horses is rare compared to other species. Detailed information such as neurological, electroencephalographic, and histopathological examination of horses with intracranial neoplasia associated with seizures is scarce in the literature. Furthermore, ganglioglioma has not been reported in the horse. A 7-year-old Quarter horse cross Paint gelding was examined due to recurre…
  • Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs. [Journal Article]
    J Comp Pathol 2019; 172:11-16Cornax I, Pluhar GE, … O'Sullivan MG
  • Two cases of high-grade glioma comprising sheets of oligodendroglial cells multifocally disrupted by regions of remarkable neuronal differentiation are described. These tumours morphologically resemble 'oligodendroglioma with ganglioglioma-like maturation', a rare tumour of man, but appear to be phenotypically more aggressive. Neuronal markers (synaptophysin, neuron-specific enolase and βIII-tubu…
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