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(gastric inhibitory polypeptide)
3,178 results
  • The early history of GIP 1969-2000: from enterogastrone to major metabolic hormone. [Review]
    Peptides 2019; :170155Marks V
  • This paper describes the early history of Gastric Inhibitory Polypeptide, better referred to simply as GIP, from its isolation by purification from a crude preparation of CCK-PZ (cholecystokinin/pancreozymin) to its recognition as a key play in the pathogenesis of obesity and other metabolic disorders far removed from the enterogastrone properties by which it was originally identified. Augmentati…
  • StatPearls: Physiology, Gastric Inhibitory Peptide [BOOK]
    StatPearls Publishing: Treasure Island (FL) Gupta Kashvi K University of Michigan Raja Avais A BOOK
  • The glucose-dependent insulinotropic polypeptide, formerly known as gastric inhibitory peptide (GIP) was first isolated in 1973 from porcine small intestine based on its ability to inhibit gastric hydrochloric acid secretion. Soon after, in 1980, it was found that GIP is a weak inhibitor of acid secretion and potent stimulator of insulin post meals.[1] This phenomenon of higher insulin secretion …
  • The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review. [Review]
    Int J Mol Sci 2019; 20(17)Mathiesen DS, Bagger JI, … Knop FK
  • The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. Furthermore, GLP-1 inhibits glucagon secretion when plasma glucose concentrations are above normal fasting concentrations while GIP acts glucagonotropically at low glucose levels. A…
  • Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. [Journal Article]
    J Clin Invest 2019; 130:3786-3791Kaneko K, Fu Y, … Fukuda M
  • Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises from excess caloric intake and negatively controls hypothalamic leptin action. We found that deficiency of the gastric inhibitory polypeptide receptor (Gipr) for the gut-derived increti…
  • Metabolic hormones and breast cancer risk among Mexican American Women in the Mano a Mano Cohort Study. [Journal Article]
    Sci Rep 2019; 9(1):9989Shen J, Hernandez D, … Zhao H
  • C-peptide, insulin, leptin, and other metabolic hormones are assumed to play roles in breast cancer development; though, results are inconsistent. In this prospective case-control study nested within the Mano a Mano Cohort Study, we assessed the risk of breast cancer with regard to plasma levels of c-peptide, gastric inhibitory polypeptide, insulin, leptin, monocyte chemoattractant protein-1, pan…
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