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1,724 results
  • Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent. [Journal Article]
    J Antimicrob Chemother 2019Britto CD, Dyson ZA, … Pollard AJ
  • CONCLUSIONS: Enteric fever in South India continues to be a major public health issue and is strongly associated with antimicrobial resistance. Robust microbiological surveillance is necessary to direct appropriate treatment and preventive strategies. Of particular concern is the emergence and expansion of the highly fluoroquinolone-resistant triple-mutant S. Typhi clone and its ongoing inter- and intra-country transmission in South Asia, which highlights the need for regional coordination of intervention strategies, including vaccination and longer-term strategies such as improvements to support hygiene and sanitation.
  • Ultrasound-assisted gatifloxacin delivery in mouse cornea, in vivo. [Journal Article]
    Sci Rep 2019; 9(1):15532Jegal U, Lee JH, … Kim KH
  • Gatifloxacin is a 4th generation fluoroquinolone antibiotic used in the clinic to treat ocular infection. One limitation of gatifloxacin is its relatively poor corneal penetration, and the increase of its trans-corneal delivery would be beneficial to reduce the amount or frequency of daily dose. In this study, ultrasound treatment was applied to enhance the trans-corneal delivery of gatifloxacin …
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Fluoroquinolones [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The fluoroquinolones are a family of broad spectrum, systemic antibacterial agents that have been used widely as therapy of respiratory and urinary tract infections. Fluoroquinolones are active against a wide range of aerobic gram-positive and gram-negative organisms. Gram-positive coverage includes penicillinase- and non-penicillinase producing Staphylococci, Streptococcus pneumoniae and viridan…
  • Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols. [Journal Article]
    Appl Microbiol Biotechnol 2019; 103(21-22):9013-9022Xu M, Xue H, … Zheng G
  • This work aimed at investigating the chemical composition, antibacterial properties, and effect mechanism of Smilax china L. polyphenols (SCLP). SCLP was extracted and purified, and then, its eighteen polyphenolic compounds were identified by LC-MS/MS analysis. SCLP exhibited antibacterial activity against five bacteria (Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, Bacil…
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