- Bilateral Necrotizing Herpes Simplex Keratitis in an Immunocompetent Patient With Genetic Analysis of Human Simplex Virus 1. [Journal Article]
- CCornea 2019 Jun 12
- CONCLUSIONS: We successfully performed an unprecedented genetic analysis of an HSV-1 strain isolated from a case of bilateral necrotizing HSK in an immunocompetent patient. The association of the HSV-1 genotype with the clinical manifestation remains unclear, calling for more data from new cases, especially from different geographic regions.
- Bacterial Keratitis: Isolated Organisms and Antibiotic Resistance Patterns in San Francisco. [Journal Article]
- CCornea 2018; 37(1):84-87
- CONCLUSIONS: Gram-positive organisms are the most commonly identified etiology of microbial keratitis in this series. Approximately 35% of cultured organisms had variable susceptibility to moxifloxacin, and resistance seems to be increasing over time. The risk of culturing MRSA increased over time.
- A serious adverse surgical event: Management of suspected HSV-1 keratitis in a donor cornea. [Journal Article]
- SASpektrum Augenheilkd 2017; 31(1):19-22
- CONCLUSIONS: Containers to transport corneoscleral discs should enable microscopic examination by the surgeon prior to use. High dose systemic antivirals may reduce the risk of herpetic disease involving the posterior segment of the eye and neuroretina in the aphakic eye and spread to the central nervous system.
- Geographic Disparities in the Etiology of Bacterial and Fungal Keratitis in the United States of America. [Review]
- SOSemin Ophthalmol 2016; 31(4):345-52
- Infectious keratitis is a serious cause of vision loss. Proper treatment of infectious keratitis requires antimicrobials that target the organism responsible for a patient's ulcer. The frequency of i…
Infectious keratitis is a serious cause of vision loss. Proper treatment of infectious keratitis requires antimicrobials that target the organism responsible for a patient's ulcer. The frequency of infection by a given organism varies by location. We examined the literature to determine geographic disparities in the etiology of bacterial and fungal keratitis in the United States of America. Bacterial keratitis makes up a greater proportion of cases in northern locations, and fungal keratitis increases in prevalence in southern locations. Gram-negative organisms make up a greater proportion of bacterial keratitis in southern locations when compared to northern locations.
- Epidemiology and etiological diagnosis of infective keratitis in eastern region of Nepal. [Journal Article]
- NJNepal J Ophthalmol 2015 Jan-Jun; 7(1):10-5
- CONCLUSIONS: Corneal ulcer continues to be one of the leading causes of preventable blindness in this region. Lack of awareness about gravity of this disease, financial constraints and geographic barriers remain the major reasons for delay in seeking proper medical help.
- Seasonal, geographic, and antimicrobial resistance patterns in microbial keratitis: 4-year experience in eastern Pennsylvania. [Journal Article]
- CCornea 2015; 34(3):296-302
- CONCLUSIONS: Most infectious keratitis occurred in nonwinter months and in patients from suburban counties. Although fluoroquinolones were effective against the most common bacteria, staphylococcal species exhibited a high rate of resistance, representing a therapeutic challenge given the increasing use of fluoroquinolones as first-line monotherapy. No organisms tested were resistant to tobramycin, gentamicin, vancomycin, or voriconazole.
- Resistant Microbial Keratitis in South Nile Delta, Egypt: Influence of Regional Risk Factors. [Journal Article]
- SOSemin Ophthalmol 2016; 31(5):473-8
- CONCLUSIONS: Higher incidence of affections and complications has appeared in farmers, rural area residents, and illiterates which are considered the main predisposing factors for ulcer resistance. According to culture results, bacterial organisms (especially Staphylococcus aureus) were the main cause of resistant corneal ulcers.
- Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta4. [Review]
- ANAnn N Y Acad Sci 2010; 1194:199-206
- Neurotrophic corneal defects are difficult to heal and all too often lead to scarring and vision loss. Medical management is often of limited success. We describe the results of nine patients (ages 3…
Neurotrophic corneal defects are difficult to heal and all too often lead to scarring and vision loss. Medical management is often of limited success. We describe the results of nine patients (ages 37-84) with chronic nonhealing neurotrophic corneal epithelial defects who were treated with thymosin beta 4 (Tbeta4) sterile eye drops for 28 or 49 days with a follow-up period of 30 days. Those with geographic defects (six patients) showed dramatic healing without clinically significant neovascularization. Stromal thinning was observed in one patient. Three patients with punctate epithelial defects did not have a demonstrable change in their clinical findings. Reduced ocular irritation was reported by all patients soon after treatment initiation. Results from these compassionate use cases indicate that Tbeta4 may provide a novel, topical approach to wound healing in chronic nonhealing neurotrophic corneal ulcers.
- Recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization. [Case Reports]
- CCornea 2010; 29(4):465-7
- CONCLUSIONS: Herpes simplex keratitis can recur after verteporfin photodynamic therapy for corneal neovascularization.
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- Primary conjunctival herpetic geographic ulcer in an immunocompetent patient. [Case Reports]
- CTCompr Ther 2007; 33(1):36-8
- Herpes simplex virus ocular infections have been recognized as a major cause of corneal blindness in the developed world. The major signs of a primary infection are limited to the lids, conjunctiva, …
Herpes simplex virus ocular infections have been recognized as a major cause of corneal blindness in the developed world. The major signs of a primary infection are limited to the lids, conjunctiva, and cornea. Presence of a conjunctival dendrite without corneal involvement has been reported. Although conjunctival ulceration has been associated with recurrent attacks, it has not been documented as a manifestation of primary herpetic infection. We report a case of primary herpetic infection with geographic conjunctival ulcer with multiple corneal dendrites.