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(germ cell aplasia germinal cell aplasia)
60 results
  • StatPearls: Sertoli-Cell-Only Syndrome [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Ramphul Kamleshun K Shanghai Jiao Tong University Zulfiqar Hassam H Rawalpindi Medical University Mejias Stephanie G. SG UNIBE University BOOK
  • Sertoli cell-only syndrome (SCO) is also known as Del Castillo syndrome and germ cell aplasia. Sertoli cells are found in the convoluted seminiferous tubules and form part of the blood-testis barrier in males. They also play an important role in spermatogenesis which is sperm production. The cells respond to a hormone called follicle-stimulating hormone (FSH) that is released by the hypothalamus.…
  • Deficient expression of JMJD1A histone demethylase in patients with round spermatid maturation arrest. [Journal Article]
    Reprod Biomed Online. 2017 Jan; 34(1):82-89.Eelaminejad Z, Favaedi R, … Shahhoseini M
  • JMJD1A (jumonji domain-containing 1A), a known histone H3K9 demethylase, has been identified as a critical epigenetic regulator in male germ cells, activating the sperm chromatin-packaging genes encoding protamines (PRM) and transition proteins (TNP) required for spermatid elongation and condensation. This research investigated the expression pattern of JMJD1A protein in testicular biopsies of 79…
  • Immunohistochemical measurement and expression of Mcl-1 in infertile testes. [Journal Article]
    Front Med. 2015 Sep; 9(3):361-7.Hegazy R, Hegazy A, … Salem E
  • The diagnosis of azoospermia represents a major challenge to andrologists as this condition may occur despite normal spermatogenesis and genital tracts. Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins involved in regulation of apoptosis in various cell types. This study aimed to investigate the immunohistochemical expression of Mcl-1 in testicular biopsies of subjects …
  • Endotext: Primary Testicular Failure [BOOK]
    . MDText.com, Inc.: South Dartmouth (MA)Feingold KR, Anawalt B, … Wilson DPBehre HM, Bergmann M, … Tüttelmann FBOOK
  • Primary testicular failure may result in endocrine failure, leading to testosterone deficiency or exocrine failure causing impaired spermatogenesis and subsequently male infertility. While some aspects of primary testicular failure are described in detail in separate chapters of Endotext.com, this chapter focuses on congenital or acquired anorchia, Leydig cell hypoplasia, and spermatogenic failur…
  • Sertoli cell only syndrome: Status of sertoli cell maturation and function. [Journal Article]
    Indian J Endocrinol Metab. 2012 Dec; 16(Suppl 2):S512-3.Jain M, Halder A
  • CONCLUSIONS: We conclude that Sertoli cell immaturity does not play any role in SCOS (no case of high AMH). It seems, in majority cases, Sertoli cells are functionally- and/or numerically-deficient (low inhibin B, AMH and lactate). However, in about 22% cases, Sertoli cell function and/or number remains normal (normal inhibin B, AMH). Inhibin B and FSH seems best predictor/marker of Sertoli cell function.
  • Immunohystochemical analysis of CFTR in normal and disrupted spermatogenesis. [Journal Article]
    Syst Biol Reprod Med. 2013 Feb; 59(1):53-9.Teixeira S, Sá R, … Sousa M
  • Cystic fibrosis is the most frequent autosomal recessive disease in the Caucasian population, with an incidence of 1:2500 newborn and a frequency of 1:25. The associated gene is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and it encodes the CFTR protein that functions as a chloride (Cl(-)) channel. It is found in the apical membrane of exocrine epithelial cells, responsible for the…
  • Sertoli cell development and function in an animal model of testicular dysgenesis syndrome. [Journal Article]
    Biol Reprod. 2008 Feb; 78(2):352-60.Hutchison GR, Scott HM, … Sharpe RM
  • Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndrome (TDS) in male offspring. Earlier studies suggested altered Sertoli cell development/maturation may result, especially in testes that become cryptorchid. This study quantitatively assessed Sertoli cell numerical and functional development in DBP-exposed rats and compared (unilaterally) cryptorchi…
  • [Immune-testicular regulation and cytokines]. [Review]
    Invest Clin. 2007 Mar; 48(1):107-21.Vivas-A G, Lozano-H J, Velasco J
  • The pathogenesis of male infertility can be reflected in alterations of spermatogenesis caused by testicular cancer, aplasia of the germinal cells, varicocele, environmental factors or defect in the transport of the sperms, among others. In general, 48% of men suffer unexplained infertility. During a long time, the masculine reproductive tract and the immune system have been studied as different …
  • What is the indication of varicocelectomy in men with nonobstructive azoospermia? [Journal Article]
    Urology. 2007 Feb; 69(2):352-5.Lee JS, Park HJ, Seo JT
  • CONCLUSIONS: Microsurgical varicocelectomy may offer patients with nonobstructive azoospermia an opportunity to have sperm in their ejaculate and even the possibility of natural conception. Microsurgical varicocelectomy can be considered a viable option in selective patients with nonobstructive azoospermia and varicocele, instead of the less cost effective and more bothersome assisted reproductive techniques.
  • Expression of beta-catenin in human testes with spermatogenic defects. [Journal Article]
    Arch Androl. 2005 Jul-Aug; 51(4):271-6.Lee JH, Choi KW, … Gye MC
  • beta-catenin is a multifunctional molecule that functions in intercellular adhesion and signal transduction during assembly of AJs between Sertoli cells as well as between Sertoli cells and germ cells. To assess changes in the testicular beta-catenin in male infertility conditions, testicular tissues from obstructive azoospermia with normal spermatogenesis, spermatogenic arrest (SA) and Sertoli c…
  • [Non-obstructive azoospermia: 2 new cases of Sertoli cell only syndrome]. [Case Reports]
    Arch Esp Urol. 2003 Dec; 56(10):1127-32.Jalón Monzón A, Martín Benito JL, … Regadera Sejas FJ
  • CONCLUSIONS: The Sertoli cell only syndrome is an entity in which seminiferous tubules show a total absence of germ cells with Sertoli cells alone. Etiology is unknown in most cases. Testicular biopsy is performed in these azoospermic men to rule out tubular obstruction or abnormalities of the spermatogenesis. Assisted reproduction techniques are a therapeutic option, making genetic counselling necessary due to the risk of transmission of the genetic defects that cause male infertility.
  • Evaluation of FSH, LH and testosterone levels in different subgroups of infertile males. [Journal Article]
    Indian J Clin Biochem. 2004 Jan; 19(1):45-9.Babu SR, Sadhnani MD, … Reddy PP
  • Gonadotropins (FSH, LH) and testosterone are the prime regulators of germ cell development. Abnormal spermatogenesis is often associated with altered serum gonadotropins and testosterone. FSH, LH and testosterone levels were estimated in 96 infertile men of whom 35 were azoospermic, 35 were oligozoospermic, 11 were with varicocele and 15 were with histopathological abnormalities like hypospermato…
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