- ANTIOXIDANT PROTECTION STATUS AND LIPOPEROXIDATION PROCESSES IN WOMEN WITH PREMATURE BIRTH IN DIFFERENT TERMS OF GESTATION. [Journal Article]
- GMGeorgian Med News 2019; (287):20-25
- The purpose of the study is examination the dynamics of antioxidant defense indicators and lipoperoxidation processes in women with pregnancy termination different periods. 227 pregnant women were ex…
The purpose of the study is examination the dynamics of antioxidant defense indicators and lipoperoxidation processes in women with pregnancy termination different periods. 227 pregnant women were examined, 190 of them had clinical signs of premature birth in the gestation period of 23-36 weeks. Formation of clinical groups was carried out depending on the term of pregnancy in the form of premature and timely birth. 48 women with early pregnancy termination were included in group I, which ended in childbirth in the period from 23 to 27 weeks. All pregnant women with risk of early pregnancy termination had the following distribution depending on the gestational period: 23-25 weeks - 23 pregnant women (Ia subgroup); 26-27 weeks - 25 pregnant women (Ib subgroup). 142 women were included in group II with late term pregnancy termination in the period from 28 to 36 weeks, which depending on the term of premature birth were divided into subgroups: IIa - 38 people, 28-30 weeks; IIb - 48 people, 31-33 weeks; IIс - 56 people, 34-36 weeks. The III (control) group included 37 women with a physiological course of pregnancy, which ended in childbirth without complications at the time of 38-41 weeks. The criteria for including women into groups were: young reproductive age, single-pregnancy, absence of gestosis, acute and chronic gynecological and somatic diseases. Diagnosis of preterm labor was carried out in the presence of abdominal pain syndrome and structural changes in the cervix. The research was carried out in compliance with the bioethics principles. In women with pregnancy termination in the period of 23-36 weeks in relation to women with the physiological course of pregnancy, which ended with childbirth without complications in the period of 38-41 weeks, there is an imbalance in the work of first and second lines antioxidants of antioxidant defense, which provokes the generation of oxygen excessive amounts active forms, initiating processes of lipoperoxidation with the essential malonic dialdehyde formation. In women with termination of pregnancy in the early stages of 23-27 weeks in relation to women with the physiological course of pregnancy there is a tension in antioxidant defense with a significant increase in lipoperoxidation, which is confirmed by a decrease in the activity of superoxide dismutase (34%), an increase in the level of ceruloplasmin (87%), diene (30%), malonic dialdehyde (by 178%), Schiff bases (by 28%) with an ambiguous change in the activity of catalase - an increase of 28% in the period of 23-25 weeks, a decrease by 16% in the period of 26-27 weeks. In women with termination of pregnancy in late periods of 28-36 weeks in relation to women with the physiological course of pregnancy, the inclusion of compensatory reactions of antioxidant defense against the background of lipoproxidation increase is observed, which is confirmed by an increase in the activity of SOD (17%), glutathione peroxidase (24%), CP (117%), diethine (by 55%), MDA (by 106%), and SBs (by 18%) with a decrease in catalase activity (by 45%). The antioxidant protection imbalance of the body and the intensification of lipoperoxidation processes is one of the components of pregnancy termination pathogenesis and may contribute in combination with other complications.
- Role of uterine blood flow disturbances in the development of late gestosis. [Journal Article]
- WLWiad Lek 2018; 71(9):1719-1721
- CONCLUSIONS: Conclusions: The findings show the increase in resistance of preplacental bed vessels in women with untreated CE in past history at the aforementioned stage, and the more apparent are the curves of blood flow rate at this stage, the more severe will be the follow-up course of preeclampsia.
- [Preeclampsia - a disease of pregnant women]. [Review]
- PBPostepy Biochem 2018 Dec 29; 64(4):232-229
- Preeclampsia, also known as EPH-gestosis, is a pregnancy-specific syndrome. It affects 3-5% of pregnant women and is characterized by edemas, high blood pressure and proteinuria. Moreover, in women w…
Preeclampsia, also known as EPH-gestosis, is a pregnancy-specific syndrome. It affects 3-5% of pregnant women and is characterized by edemas, high blood pressure and proteinuria. Moreover, in women with preeclampsia dysfunction of many organs, such as kidney and liver, is diagnosed, while in the case of fetus growth restriction is observed. Preeclampsia, when left untreated, can lead to death. In low-income countries, this disorder is one of the main causes of maternal and child mortality. Preeclampsia predisposes women in later life to cardiovascular diseases. So far, in acute cases of preeclampsia stabilization of the mother and fetus and finally termination of pregnancy at a time optimal for both sides can only be considered. In this work, available literature data concerning the causes of preeclampsia, its symptoms, techniques for diagnosis, methods for prevention and new approaches to treatment were collected.
- Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center. [Journal Article]
- CNChilds Nerv Syst 2019; 35(2):283-293
- CONCLUSIONS: Stroke is still a common and dreadful events in perinatal period as this disorder is often unpredictable and cause of severe neurological impairment.
- PECULIARITIES OF THE COURSE OF GESTATION AND PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS. [Journal Article]
- AEActa Endocrinol (Buchar) 2018 Apr-Jun; 14(2):213-218
- CONCLUSIONS: GDM significantly worsens course of gestation.
- Spontaneous hepatic rupture in a bodybuilder: a case report and review of the literature. [Case Reports]
- RERev Esp Enferm Dig 2018; 110(4):254-256
- This article is the first description of a spontaneous hepatic rupture in a young bodybuilder with a history of clenbuterol and ephedrine alkaloid use. The patient presented with a sudden mid-epigast…
This article is the first description of a spontaneous hepatic rupture in a young bodybuilder with a history of clenbuterol and ephedrine alkaloid use. The patient presented with a sudden mid-epigastric pain and vomiting. Hemoglobin levels decreased a few hours later and a computed tomography scan was performed which revealed a rupture of the right liver capsule and hemoperitoneum. Two attempts at transarterial embolization did not control the bleeding and a right hemihepatectomy was performed. The pathological report identified a hepatic adenoma, a capsular tear and diffuse peliosis hepatis. The patient was discharged in a good condition after eleven days. Spontaneous hepatic ruptures are rare and life-threatening and are usually described in association with tumors, connective tissue diseases and gestosis. This article is a review of the available literature with regard to this condition, with a focus on its relation to peliosis hepatis and banned substance used by body image fanatics. The present case highlights the challenging diagnosis of this potentially fatal liver complication in a healthy appearing male, the risk associated with the online trade of performance enhancing drugs and its relation with peliosis hepatis.
- Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. [Journal Article]
- ESEnviron Sci Pollut Res Int 2018; 25(32):31885-31894
- Organochlorine pesticides (OCPs) were determined by gas chromatography in 241 placentas from cotton-growing regions, 121 placentas from an urban area (city of Osh), and 146 placentas from unpolluted …
Organochlorine pesticides (OCPs) were determined by gas chromatography in 241 placentas from cotton-growing regions, 121 placentas from an urban area (city of Osh), and 146 placentas from unpolluted mountain regions of Kyrgyzstan. Manifestations of disease were recorded in the mothers during pregnancy and parturition and in their newborns during the first 6 days of life. OCPs were detected in 240 out of 508 placentas (47.2%), with increased incidence in the two polluted regions (65%), particularly in placentas from women living near former pesticide storehouses and agro air-strips (99%), but only in 2.7% of placentas from the unpolluted region. α-, β-, and γ-hexachlorocyclohexane (HCH); DDT; DDE; aldrin; and heptachlor were detected. The sum of concentrations of all OCPs (total OCPs) was calculated for each of the 240 placentas with detectable OCPs (median 9.5 μg/kg placenta, mean 88.3 μg/kg, range 0.1-3070 μg/kg). The incidence of health problems in four subgroups of this data set, with increasing levels of total OCPs, was compared with the incidence of health problems in the group of 268 placentas, where OCPs were undetectable. Relative risk of health problems in both, mothers and newborns, increased significantly, in a concentration-dependent manner, with increasing levels of total OCPs (p < 0.0001). Health complications with increased incidence in OCP-exposed newborns included, i.a., low birth weight, congenital malformations, infections, and stillbirths, in OCP-exposed mothers preterm delivery, (pre-)eclampsia/gestosis, and frequency of hospitalizations after delivery (infections). Women living near former pesticide storehouses and agro airstrips should be considered as being at risk. Reduction of exposure is urgently needed.
- The dietary composition of women who delivered preterm and full-term infants. [Journal Article]
- ANAppl Nurs Res 2017; 35:13-17
- CONCLUSIONS: Statistically significant differences in average daily intake of folates, iodine, retinol, magnesium and iron were observed between the group of women with vaginal delivery at term and the groups of women with diagnosed hypertension who delivered preterm. Correlation was demonstrated between average daily intake of iodine and vitamin D and the occurrence of arterial hypertension. Supplementation of the diet of women in the preconception and prenatal period with minerals and vitamins should be considered.
- Immunohistochemical evaluation of the influence of L-arginine on biomarkers of environmental (cellular) stress in the kidneys of pregnant female rats. [Journal Article]
- AAAnn Agric Environ Med 2017 Mar 31; 24(1):121-128
- CONCLUSIONS: L-arginine increased the expression of p-53 protein - on the 10th day of pregnancy, which increased at the end of pregnancy; however, 10 days after delivery the level dropped below that observable during physiological pregnancy. Hormonal changes in physiological pregnancy cause an increase in expression of the p-53 (cell stress marker) in the epithelial cells of renal tubules, mainly at the end of pregnancy (20th day). 10 days after the delivery, this expression decreases. The expression of HSP-70 protein increases already on the 10th day of pregnancy and maintains a similar level throughout the pregnancy, but is reduced after the puerperium.
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- Characteristics and management of mirror syndrome: a systematic review (1956-2016). [Case Reports]
- JPJ Perinat Med 2017 Dec 20; 45(9):1013-1021
- CONCLUSIONS: The gestational age at diagnosis and sequence of presentation have insignificant impact on fetal outcome. Improved fetal survival was associated with procedural interventions that correct fetal hydrops as well as labor induction.