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4,545 results
  • Concise asymmetric synthesis of (-)-bilobalide. [Journal Article]
    Nature 2019Baker MA, Demoret RM, … Shenvi RA
  • The Ginkgo biloba metabolite bilobalide is widely ingested by humans but its effect on the mammalian central nervous system is not fully understood1-4. Antagonism of gamma-aminobutyric acid A receptors (GABAARs) by bilobalide has been tied to rescue of cognitive deficits in mouse models of Down syndrome5. A lack of convulsant activity coupled with these neuroprotective effects have led some to po…
  • Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology. [Journal Article]
    Comb Chem High Throughput Screen 2019; 22(6):411-420Wu XJ, Zhou XB, … Mao W
  • Cardiovascular disease is a serious threat to human health because of its high mortality and morbidity rates. At present, there is no effective treatment. In Southeast Asia, traditional Chinese medicine is widely used in the treatment of cardiovascular diseases. Quercetin is a flavonoid extract of Ginkgo biloba leaves. Basic experiments and clinical studies have shown that quercetin has a signifi…
  • Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway. [Journal Article]
    Molecules 2019; 24(19)Bu S, Yuan CY, … Cao F
  • Bilobalide, the only sesquiterpene compound from Ginkgo biloba leaf, exhibits various beneficial pharmaceutical activities, such as antioxidant, anti-inflammation, and protective effects for the central nervous system. Several bioactive components extracted from Ginkgo biloba extract reportedly have the potential to attenuate lipid metabolism. However, the effect of bilobalide on lipid metabolism…
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